| 缓激肽及其类似物RMP-7对血脑屏障通透性的影响 |
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| 引用本文： | 王玉勤,薛一雪. 缓激肽及其类似物RMP-7对血脑屏障通透性的影响[J]. 解剖科学进展, 2005, 11(4): 373-376 |
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| 作者姓名： | 王玉勤 薛一雪 |
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| 作者单位： | 辽宁中医学院职业技术学院生理学教研室,辽宁,沈阳,110101;中国医科大学神经生物学教研室,辽宁,沈阳,110001 |
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| 基金项目： | 国家自然科学基金资助项目（No.30070268,30070768,30400145）;辽宁省自然科学基金（No.20022067,20022061） |
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| 摘 要： | 缓激肽及其类似物RMP-7能选择性增加血肿瘤屏障的通透性,而对正常脑组织的血脑屏障几乎无影响。研究表明,缓激肽选择性开放血脑屏障是由于缓激肽与大脑毛细血管内皮细胞膜上的B2受体结合,引起细胞内Ca2+水平升高,从而引发包括NO和cGMP在内的一系列的信号传递反应,使胞饮小泡数量增加或紧密连接开放。本文就缓激肽及其类似物RMP-7选择性开放血脑屏障的新进展做一综述。
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| 关 键 词： | 血脑屏障通透性 RMP-7 缓激肽 类似物 毛细血管内皮细胞 正常脑组织 受体结合 Ca2＋ 信号传递 cGMP |
| 文章编号： | 1006-2947(2005)04-0373-04 |
| 收稿时间： | 2005-09-01 |
| 修稿时间： | 2005-09-01 |
The Effect of Bradykinin or RMP-7 on the Permeability of Blood Brain Barrier |
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| WANG Yu-qin,XUE Yi-xue. The Effect of Bradykinin or RMP-7 on the Permeability of Blood Brain Barrier[J]. Progress of Anatomical Sciences, 2005, 11(4): 373-376 |
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| Authors: | WANG Yu-qin XUE Yi-xue |
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| Affiliation: | 1. Department of Physiology, Vocational Technology College, Liaoning Chinese Traditional Medicine University, Liaoning Shenyang 110101 ; 2. Department of Neurobiology,China Medical University,Liaoning Shenyang 110001 China |
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| Abstract: | Bradykinin and its analog RMP-7 significantly increase the permeability of the blood tumor barrier,but is unaffected for the normal blood brain barrier.The possible mechanism is that the binding of the bradykinin with B_2 receptor on capillary endothelial cells causes the transient increase of the level of intracellular Ca~(2+),eliciting a cascade of signal transduction reactions including the rise of NO and cGMP,leading to the increase of the pinocytic vesicles number or the opening of the tight junction.The article reviews the progress of the selective increase of the permeability of the blood brain barrier induced by bradykinin and RMP-7. |
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