In vivo tracking of human mesenchymal stem cells in experimental stroke |
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Authors: | Kim Daehong Chun Byoung-Gi Kim Yeon-Kyung Lee Yong Hyun Park Cheong-Soo Jeon Iksoo Cheong Chaejoon Hwang Tae-Sun Chung Hyungmin Gwag Byoung Joo Hong Kwan Soo Song Jihwan |
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Affiliation: | MRI Team, Korea Basic Science Institute, Ochang, Korea. |
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Abstract: | To understand the fates of human mesenchymal stem cells (hMSCs) following transplantation into a rodent model of middle cerebral artery occlusion (MCAo), magnetic resonance imaging (MRI) techniques were employed, hMSCs were labeled with ferumoxides (Feridex)--protamine sulfate complexes, which were visualized and examined by MRI up to 10 weeks following transplantation. Migration of the transplanted cells to the infarcted area was further confirmed by histological methods. We found that the hMSCs transplanted in MCAo models possess the capacity to migrate to the infarcted area extensively in both ipsilateral and contralateral injections, exhibiting a pathotropism. We also analyzed the detailed migration patterns of transplanted hMSCs. We speculate that the extensive migratory ability of hMSCs may represent a therapeutic potential for developing efficient cell transplantation strategies in stroke. |
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