贝尼地平对原发性高血压患者胰岛素抵抗的影响

目的观察贝尼地平对原发性高血压（EssentialHypertension，EH）患者胰岛素抵抗的影响。方法轻、中度EH患者65例，予以贝尼地平治疗8周，并按体重指数（BMI）将其分为两组：BMI≥25者为EH肥胖组，29例；BMI〈25者为EH非肥胖组，36例。同期选择健康体检者30例作为对照组。检测受试者入选时和8周后血压、空腹血糖、血浆胰岛素，并用胰岛素敏感指数评价胰岛素抵抗。结果与治疗前比较，EH非肥胖组的胰岛素敏感性改善明显（P〈0．05），而EH肥胖组无明显改善（P〉0．05）。结论贝尼地平能改善非肥胖EH患者的胰岛素敏感性，而对EH肥胖患者改善不明显。

Effects of Benidipine on insulin resistance in patients with essential hypertension

Objective To study the effects of Benidipine on insulin resistance in patients with essential hyper tension. Methods 65 patients with mild to moderate essential hypertension administed Benidipine were divided in- to two groups by body mass index （BMI） ： 29 obese patients with EH and BMI ≥ 25 and 36 non - obese patients with EH and BMI 〈 25. 30 health people were selected as control group. Blood pressure, fasting blood sugar, fasting insulin were measured in all subjects. Insulin resistance was evaluated by insulin sensitivity index （ISI）. Results Compared with pre - treatment, the insulin sensitivity of EH non - obese group ameliorated considerably （ P 〈 0.05）, while no significant improvement was found on the EH obese patients （ P 〉 0.05）. Conclusion Be- nidipine can improve insulin sensitivity in non- obese EH patients, but not in obese EH patients.