| 萘丁美酮对小鼠免疫功能的影响 |
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| 引用本文： | 周世文,姚娉,康钦树.萘丁美酮对小鼠免疫功能的影响[J].中国药房,2001,12(5):269-269. |
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| 作者姓名： | 周世文 姚娉 康钦树 |
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| 作者单位： | 第三军医大学新桥医院临床药理基地, |
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| 摘 要： | 目的 :研究萘丁美酮对小鼠免疫功能的影响。方法 :小鼠灌胃萘丁美酮后 ,分别观察胸腺、脾脏重量 ,腹腔巨噬细胞吞噬功能和游走功能 ,体内PHA诱导的淋巴细胞转化。结果 :萘丁美酮能明显减轻小鼠胸腺和脾脏重量 ,降低小鼠腹腔巨噬细胞吞噬游走功能 ,抑制PHA诱导的小鼠淋巴细胞转化。结论 :萘丁美酮对小鼠细胞免疫功能有明显的抑制作用。
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| 关 键 词： | 萘丁美酮 免疫功能 巨噬细胞 淋巴细胞转化 |
| 文章编号： | 1001－ 0408（ 2001） 05－ 0268－ 02 |
| 修稿时间： | 2001年1月10日 |
Effects of Nabumetone on Immunological Functions in Mice |
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| Zhou Shiwen,YAO Ping,KANG Qinshu.Effects of Nabumetone on Immunological Functions in Mice[J].China Pharmacy,2001,12(5):269-269. |
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| Authors: | Zhou Shiwen YAO Ping KANG Qinshu |
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| Abstract: | AIM:To study the effects of nabumetone on immunological fuctions in mice METHODS:After nabumetone was given ig to mice,the weight of thymus and spleen,phagocytizing function of macrophages,PHA-induced lymphocyte transformation were observed respectively in mice RESULTS:The weight of thymus and spleen was decreased,the phagocytizing function of macrophages was reduced,PHA-induced lymphocyte transformation was markedly inhibited with nabumetone in mice CONCLUSION:The immunological function in mice was significantly inhibited with nonsteriod anti-inflammatory drug-nabumetone |
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| Keywords: | nabumetone immunological function macrophages lymphocyte transformation |
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