Rituximab-induced Ileocolitis in a Patient with Gastric MALToma: A Case Report and Literature Review |
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| Authors: | Yoshikazu Tsuzuki Rie Shiomi Keigo Ashitani Kazuya Miyaguchi Atsushi Osaki Hideki Ohgo Rei Kim Atsushi Sasaki Taketo Yamada Yoshitaka Miyakawa Hidetomo Nakamoto Hiroyuki Imaeda |
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| Affiliation: | 1.Department of Gastroenterology, Saitama Medical University, Japan; 2.Department of General Internal Medicine, Saitama Medical University, Japan; 3.Department of Pathology, Saitama Medical University, Japan |
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| Abstract: | Rituximab (RTX) is effective for treating cancer, but reports of RTX-associated enterocolitis are limited. We herein report the case of a 65-year-old man who developed RTX-induced ileocolitis. He was diagnosed with gastric mucosa-associated lymphoid tissue lymphoma (MALToma) and treated with RTX. He complained of bloody diarrhea after RTX. Mucosal inflammation on colonoscopy indicated RTX-induced ileocolitis. He was treated with corticosteroids, and his symptoms improved. We reviewed the RTX-associated gastrointestinal adverse events and classified the features into ulcerative colitis, Crohn''s disease, microscopic colitis, and ileocolitis. To our knowledge, this is the first case of a Japanese patient who developed RTX-induced ileocolitis. |
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| Keywords: | rituximab ileocolitis MALToma B cells T cells inflammatory bowel disease |
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