Schizoaffective disorder and metabolic syndrome: A meta-analytic comparison with schizophrenia and other non-affective psychoses |
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| Affiliation: | 1. Department of Neurology, Neuroscience Institute, University of Cincinnati, 260 Stetson St., Suite 2300, Cincinnati, OH 45267-0525, USA;2. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45267-0559, USA;3. Department of Biomedical Sciences, Division of Biostatistics & Epidemiology, Texas Tech University Health Sciences Center, El Paso, TX, USA;4. Comprehensive Epilepsy Center, Department of Neurology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10463, USA;1. Department of Psychology, Institute of Mental Health Research, University of Texas at Austin, Austin, TX, United States;2. Department of Psychology, University of Houston, Houston, TX, United States;3. Department of Psychology, Baylor University, Waco, TX, United States;4. Department of Behavioral Sciences, University of Texas MD Anderson Cancer Center, Houston, TX, United States;5. Department of Psychology, Southern Methodist University, Dallas, TX, United States;1. Barcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, Barcelona, Spain;2. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain;3. Department of Psychiatry, University of Oviedo, Oviedo, Spain;4. Institut d''investigacions Biomèdiques August Pi i Sunyer (IDIBAPs), Barcelona, Spain;5. Department of Medicine and Psychiatry, University of Zaragoza, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain;6. BIOARABA Health Research Institute, OSI Araba, University Hospital, University of the Basque Country, Vitoria, Spain;7. Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain;8. Department of Psychiatry, Hospital de Sant Pau, Barcelona, Spain;9. Psychiatry and Department, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain;10. Child and Adolescent Psychiatry and Psychology Department, SGR489, Hospital Clinic of Barcelona, Institute of Neurosciences, University of Barcelona, Barcelona, Spain;11. Department of Psychiatry, Hospital Santiago Apóstol, University of the Basque Country, Vitoria, Spain;12. Instituto de Investigación Hospital 12 de Octubre (imas12), Madrid, Spain;13. CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, Badajoz, Spain;14. Department of Psychiatry, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain;15. Barcelona Clínic Schizophrenia Unit, Neuroscience Institute, Hospital Clínic of Barcelona, Barcelona, Spain;p. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain;q. Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), G04, Barcelona, Spain |
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| Abstract: | People with psychotic disorders, including schizophrenia (SCZ), schizoaffective disorder (SD), or other non-affective psychoses (ONAP), have a higher risk of metabolic syndrome (MetS) than general population. However, previous meta-analyses failed to explore if people with SD are more likely to suffer from MetS than SCZ and ONAP.We carried out a systematic review and meta-analysis comparing rates of MetS in SD with those in SCZ or ONAP. We searched main electronic databases for relevant articles published up to January 2015, and for unpublished data, contacting corresponding authors, to minimize selective reporting bias. Odds ratios (ORs) based on random effects models, with 95% confidence intervals (CIs), and heterogeneity (I2), were estimated. We performed leave-one-out, quality-based, and subgroups analyses to check findings validity. Testing for publication bias, Egger's test estimates were reported.We included 7616 individuals (1632 with SD and 5984 with SCZ/ONAP) from 30 independent samples. SD, as compared with SCZ/ONAP, had a random-effect pooled OR (95%CI) for MetS of 1.41 (1.23–1.61; p < 0.001; I2 = 5%). No risk of publication bias was found (p = 0.85). Leave-one-out, sensitivity, and subgroups analyses confirmed the association.To our knowledge, this is the first meta-analysis comparing MetS comorbidity between individuals with SD and those with SCZ or ONAP. SD subjects are more likely to suffer from MetS, with consistent findings across the studies included. However, the role of explanatory factors of this association, and the relative contribution of MetS subcomponents, deserve further research. |
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| Keywords: | Schizoaffective disorder Schizophrenia Psychotic disorders Metabolic syndrome Meta-analysis |
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