溶脲脲原体对大环内酯类药物的敏感性分析

目的：检测溶脲脲原体(Uu)对14环(红霉素和罗红霉素)、15环(阿奇霉素)和16环(交沙霉素和吉他霉素)大环内酯类药物的敏感性，为临床合理用药提供参考依据。方法：采用微量肉汤稀释法检测了5种大环内酯类药物对203株Uu的最低抑菌浓度(MIC)。结果：203株Uu对红霉素、罗红霉素、阿奇霉素、交沙霉素和吉他霉素的耐药率分别为：11．8％、7．4％、6．9％、3．9％和3．5％。在5种药物中，交沙霉素和吉他霉素抗Uu活性最强，MIC50分别为0．125mg／L和0．5mg／L，MIC90分别为0．5mg／L和1mg／L，其次为阿奇霉素，MIC50和MIC90分别为2mg／L和4mg／L，红霉素和罗红霉素抗Uu活性较弱，MIC50均为4mg／L，MIC90均为8mg／L.结论：Uu对大环内酯类药物存在不同程度的耐药；16环大环内酯类药物交沙霉素和吉他霉素抗Uu活性强于14环和15环大环内酯类药物。

The susceptibility analysis of ureaplasma urealyticum to macrolides agents

Objective: To determine the susceptibility of ureaplasma urealyticum (Uu) to 14-membered(erythromycin and rox-ithromycin) ,15-membered(azithromycin) and 16-membered(josamycin and kitsamycin) macrolides for the rational use of antibiotics. Methods: The MIC of five macrolides against 203 strains of Uu were determined using broth microdilution method. Results: The resistant rates of 203 Uu strains were as follows: erythromycin 11.8%, roxithromycin 7.4%, azithromycin 6.9%, josamycin 3.9%, kitasamycin 3.5%. Among the five macrolides, josamycin and kitasamycin were the most active agents against Uu.the MIC50 being 0.125 mg/L and 0.5 mg/L,respectively;MIC90 being 0.5 mg/L and 1 mg/L, respectively;erythromycin and roxithromycin were less active against Uu, the MIC50 being 4 mg/L and 4 mg/L, and MIC90 being 8 mg/L and 8 mg/L. Conclusions: The degree of resistance of Uu to different macrolides varied 16-membered macrolides such as josamycin and kitasamycin are more active against Uu than 14-membered and 15-membered macrolides.