| 电渗作用对替硝唑经皮离子导入的影响 |
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| 引用本文： | 高建青,冯璇,梁文权. 电渗作用对替硝唑经皮离子导入的影响[J]. 中国医药工业杂志, 2001, 32(1): 5-7 |
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| 作者姓名： | 高建青 冯璇 梁文权 |
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| 作者单位： | 浙江大学药学院药剂教研室, |
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| 基金项目： | 国家自然科学基金资助项目(39370658) |
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| 摘 要： | 考察了电扬下电渗作用对分子型药物替硝唑经皮渗透的影响。实验结果表明，替硝唑从饱和水溶液经正极导入时，透皮速率比其被动扩散增加12.8倍，负极导入也产生一定的促进作用。替硝唑的透皮速率随电流强度而增加。另外,NaCl的加入使用电场下替硝唑的透皮速率明显下降，而在NaCl浓度为0.05mol/L时药物在电场下的透皮率相对较大。
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| 关 键 词： | 替硝唑 电渗作用 经皮离子导入 |
| 文章编号： | 1001-8255(2001)1-0005-03 |
| 修稿时间： | 1999-09-28 |
Effect of Electroosmosis on Iontophoretic Transdermal Delivery of Tinidazole |
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| GAO Jian-Qing,FEN Xuan,LIANG Wen-Quan. Effect of Electroosmosis on Iontophoretic Transdermal Delivery of Tinidazole[J]. , 2001, 32(1): 5-7 |
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| Authors: | GAO Jian-Qing FEN Xuan LIANG Wen-Quan |
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| Abstract: | The effect of electroosmosis on the transdermal delivery of molecular drug——tinidazole was investigated. The results showed that the flux of tinidazole saturated water solution with anodal iontophoresis was 12.8 times as great as the passive flux and cathodal iontophoresis also showed a certain enhance effect. The transdermal flux of tinidazole increased with the increasing of current intensity. On the other hand, added NaCl could decrease the tinidazole flux under the electric field and the relatively larger flux appeared at the NaCl concentration of 0.05 mol/L. |
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| Keywords: | tinidazole electroosmosis iontophoresis |
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