硫酸镁在快速房颤患者中的治疗作用

目的观察常规西地兰治疗外加用硫酸镁治疗房颤伴快速心室率患者的作用和安全性。方法229例急诊就诊的房颤伴快速心室率患者被随机分为两组,硫酸镁组除常规西地兰治疗外,给予硫酸镁2.5g20min内静脉注射,继之2.5g2h内静脉输液;对照组除常规西地兰治疗外加用安慰剂治疗。结果给药2h内硫酸镁组心室率降至100次/min以下者、转复为窦性心律者均显著多于安慰剂组(P<0.001或P<0.05),而两组不良反应发生率比较差异无统计学意义(P>0.05)。结论对房颤伴快速心室率患者在常规西地兰治疗外加用硫酸镁治疗可起到辅助和加强治疗效果的有益作用,并且比较安全。

Curative effect of magnesium sulfate infusion on patients with rapid atrial fibrillation

Objective To observe the safety and efficacy of magnesium sulfate infusion besides the treatment of Cedilanid for the patients with atrial fibrillation and a rapid ventricular rate.Methods This was a prospective,randomized,double-blind,placebo-controlled trial of intravenous magnesium sulfate in adult emergency department patients with rapid atrial fibrillation.Besides Cedilanid,the patients were treated with either 2.5 g magnesium sulfate for 20 minutes,then followed by 2.5 g for 2 hours intravenously,or placebo.Results 229 patients were divided at random into magnesium sulfate group(116 cases)and control group(113 cases).Magnesium sulfate was more likely than placebo to achieve a ventricular rate of less than 100 beats/min and more likely to convert to sinus rhythm(P<0.001 or P<0.05).There were no differences in adverse event between two groups(P>0.05).Conclusion Magnesium sulfate and Cedilanid is beneficial to improve the curative effect and is very safe for the patients with rapid atrial fibrillation.