Enkephalinase inhibition antagonizes the increased susceptibility to seizure induced by REM sleep deprivation |
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Authors: | Ukponmwan O. E. Dzoljic M. R. |
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Affiliation: | (1) Department of Pharmacology, Faculty of Medicine, Erasmus University Rotterdam, P.O. Box 1738, NL-3000 DR Rotterdam, The Netherlands |
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Abstract: | In order to elucidate the relationship between REM sleep and the enkephalinergic system, the effects of REM sleep deprivation (REMSD), stress and the enkephalinase inhibitor phosphoramidon on handling-induced convulsions were studied in mice. REMSD, stress and phosphoramidon (25–500 g icv) increased the frequency of handling-induced convulsions (HIC) in normal mice. However, only in the last two groups were HIC antagonized by naloxone (1 mg/kg IP). In REMSD mice, phosphoramidon decreased the frequency of HIC, this effect being abolished by naloxone. The increase of neuronal excitability during REMSD is suggested to be associated with an insufficiency of the enkephalinergic system. |
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Keywords: | REM sleep deprivation Enkephalinase inhibition Phosphoramidon Seizures Mice |
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