肝胆病患者血小板参数及聚集的相关研究

 目的 探讨肝胆病患者的血小板各参数动态变化及聚集程度的临床意义.方法 AC-970E0+血细胞分析仪,检测肝胆病患者;60例健康体检者血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、血小板分布宽度(PDW)4项参数进行测定,并对血涂片中血小板聚集程度进行观察.结果 肝炎组、肝硬化组与健康对照组相比较,PLT、MPV差异有统计学意义(P＜0.01),胆囊炎,胆石症组PLT、PDW差异无统计学意义(P＞0.05).结论 胆囊炎患者在疾病急性期时血小板聚集程度增强,肝炎、肝硬化患者PLT的数量减少,提示对PLT的研究有助于临床鉴别诊断、评估肝胆疾病方面具有一定的应用价值.

A study on Platelet parameters and conglomeration in patients with hepatobiliary Diseases

Objective To study the clinical significance of dynamic changes and conglomeration of platelets in patients of hepatobiliary diseases.Methods The patients with hepatobiliary diseases were examined using AC-970E0+platelet analyzer,and 60 healthy subjects as normal controls.Platelet distribution width(PDW),thrombocytocrit(PCT) mean platelet volume(MPV) and platelet count(PLT) were examined and platelet conglomeration in blood smear was observed.Results PLT and MPV in hepatitis and hepatocirrhosis patients were significantly different from those in the normal control group(P<0.01).PLT and PDW in the cholecystitis and cholelithiasis group did not significantly differ from those in the normal control group(P>0.05).Conclusions The platelet conglomeration is enhanced in acute cholecystitis patients,and PLT in hepatitis and hepatocirrhosis patients are decreased,suggesting that study on platelet parameters and conglomeration in patients with hepatobiliary diseases is of great significance in clinical differential diagnosis and evaluation of hepatobiliary diseases.