Urinary excretion kinetics of p-nitrophenol following oral administration of parathion in the rabbit |
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Authors: | M J Peña-Egido E L Marino-Hernandez C Santos-Buelga J C Rivas-Gonzalo |
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Institution: | (1) Department of Food Science, Toxicology and Chemical Analysis, University of Salamanca, E-37007 Salamanca, Spain;(2) Department of Practical Pharmacy, Faculty of Pharmacy, University of Salamanca, E-37007 Salamanca, Spain |
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Abstract: | The urinary excretion kinetics of p-nitrophenol were studied in rabbits following oral administration of parathion at a dose of 3 mg/kg. Elimination of p-nitrophenol began rapidly, and of the total amount excreted during the study period, 46% was excreted in the first 3 h; 85% was excreted at 6 h after administration of the pesticide. The mean maximum excretion rate of p-nitrophenol was 111.15±61.02 g/h reached in a time of 0.77±0.26 h. The formation and disappearance rate constants of the metabolite were 2.85±2.80 h–1 and 0.80±0.28 h–1, respectively. A linear relationship was observed between the plasma concentrations of parathion and the urinary excretion rate of p-nitrophenol. |
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Keywords: | Parathion p-Nitrophenol Urinary excretion Rabbit |
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