| 顶空气相色谱法测定盐酸倍他洛尔中6种有机溶剂残留量 |
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| 引用本文： | 黄宇玫,;罗文艳.顶空气相色谱法测定盐酸倍他洛尔中6种有机溶剂残留量[J].西北药学杂志,2014(4):363-365. |
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| 作者姓名： | 黄宇玫 ;罗文艳 |
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| 作者单位： | [1]南昌大学科学技术学院,南昌330029; [2]南昌大学第四附属医院药剂科,南昌330003 |
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| 摘 要： | 目的建立气相色谱法测定盐酸倍他洛尔中丙酮、乙酸乙酯、异丙醇、乙腈、甲苯、N,N-二甲基甲酰胺6种有机溶剂残留量。方法采用气相色谱法,色谱柱为DB-WAX石英毛细管柱(30.0m×0.53mm,1.0μm),载气为氮气,进样口温度为250℃,FID检测器温度为280℃;柱温为50℃,保持5min,以15℃·min-1升温速率升至200℃,维持6min,溶剂为二甲基亚砜。结果被测物均能得到很好的分离,峰面积与质量浓度线性关系良好,精密度和回收率良好。结论该方法准确、可行,可作为盐酸倍他洛尔的质量控制与评价的一种直观、合理、有效的技术手段。
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| 关 键 词： | 盐酸倍他洛尔 气相色谱法 有机溶剂残留量 |
Determination of 6 kinds of residual organic solvents in betaxolol hydrochloride by head-space gas chromatography |
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| Institution: | HUANG Yumei , LUO Wenyan (1. College of Science and Technology, Nanchang University ,Nanchang 330029 ,China; 2. Department of Pharmacy, the Fourth Affiliated Hospital of Nanchang University, Nanchang 330003 ,China) |
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| Abstract: | Objective To establish a gas chromatography method for the determination of residual organic solvents：acetone,ethyl acetate,iso-propanol,acetonitrile,toluene and N,N-dimethylformamide in betaxolol hydrochloride.Methods The residual solvents in betaxolol hydrochloride were separated by DB-624capillary column（30.0m×0.53mm,1.0μm）with FID detector.The carried gas was nitrogen.The injector temperature and detector temperature were controlled at 250℃and 280℃,respectively.The column temperature was maintained at 50℃for 5min,then raised at a rate of 15℃per min to 200℃and maintained for 6min.The sample was dissolved in dimethyl sulfoxide.Results The solvents were separated completely.The calibration curve of each solvent showed a good linear relationship with good precision and accuracy.Conclusion This method is accurate and reliable,and is an efficient method for the quality evaluation of betaxolol hydrochloride. |
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| Keywords: | betaxolol hydrochloride gas chromatography residual organic solvents |
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