| 硒对IL—1和IL—2的产生及其反应性的影响 |
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| 引用本文： | 王茹端,冯作化.硒对IL—1和IL—2的产生及其反应性的影响[J].免疫学杂志,1990,6(3):163-166. |
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| 作者姓名： | 王茹端 冯作化 |
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| 作者单位： | 武汉冶金医学专科学校生化教研室，武汉冶金医学专科学校生化教研室，同济医科大学医学分子生物学研究室，同济医科大学医学分子生物学研究室 武汉 430080，武汉 430080 |
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| 摘 要： | 本文报告硒对白细胞介素1(IL-1)和白细胞介素2(IL-2)的产生及其反应性的影响。实验结果显示:T淋巴细胞经低浓度亚硒酸钠预处理后,丝裂原诱导的IL-2活性水平显著升高,表明硒可促进IL-2的产生;在亚硒酸钠存在的条件下,T淋巴母细胞对IL-2的应答增强;硒可明显促进巨噬细胞分泌IL-1,并可促进胸腺细胞对IL-1的应答。提示硒可能通过促进IL-1的分泌和应答而间接促进IL-2的产生和应答,进而促进T细胞及其他免疫细胞的增殖和活性,以增强机体免疫功能。
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| 关 键 词： | 硒 白细胞介素 |
The Effects of Selenium on the Production and Responsiveness of Interleukin 1 and Interleukin 2 |
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| Wang Ruduan et al.The Effects of Selenium on the Production and Responsiveness of Interleukin 1 and Interleukin 2[J].Immunological Journal,1990,6(3):163-166. |
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| Authors: | Wang Ruduan |
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| Institution: | Wang Ruduan et al
Department of Biochemistry,Wuhan Medical School for Metallurgical Industry,Wuhan |
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| Abstract: | In this paper, the effects of selenium on the production and responsiveness of interleukin 1 (IL-1) and interleukin 2 (IL-2) were reported. The results showed that selenium was able to enhanced the production of IL-2 by T lymphocytes and IL-1 by macrophages in the presence of lectin and to augment the response of T lympho. blasts to IL-2 and Thymocytes to IL-1 in the presence of ConA. The data presented suggest that selenium might enhance IL-2 production and response through the augmentation of IL-1 production, by which selenium enhanced the proliferation and action of T lymphocyte and other immunocompetent cells. |
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| Keywords: | Selenium Interleukin 1 Interleukin 2 |
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