海带多糖对实验性高血脂鹌鹑的降脂及抗动脉粥样硬化作用

目的:研究海带多糖对实验性高血脂鹌鹑的降脂及抗动脉粥样硬化作用.方法:采用高脂饲料诱导鹌鹑建立高血脂动脉粥样硬化模型,注射海带多糖2 wk后,测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)浓度,计算HDL/TC值及肝脏指数;分离动脉,Sudan染色,观察动脉内膜斑块面积及动脉内膜病理改变.结论:海带多糖可显著降低血清TC、TG、LDL及肝脏指数,显著升高HDL/TC值,同时明显减少高血脂实验动物动脉内膜粥样硬化斑块面积和内膜病变程度.结论:海带多糖能很好的降低血脂,抑制动脉粥样硬化的形成.

Effect of Laminaria Japonica Polysaccharides on Lowing Serum Lipid and Anti-Atherosclerosis in Hyperlipemia Quails

Objective:To study the effect of Laminaria Japonica Polysaccharides on lowing serum lipid and anti-atherosclerosis in quails.Methods:The hyperlipemia atherosclerosis (As) models of quails were induced by high lipids.After administration with Laminaria Japonica Polysccharides for two weeks,the content of total cholesterol (TC),triglyceride (TG),high density lipoprotein (HDL) and low density lipoprotein(LDL) in serum and the ratio of HDL/TC were determined,index of liver was calculated,the extent of aortic atherosclerosis and the atherosclerotic lesion were observed.Results:The concentration of TC,TG,LDL in serum and index of liver decreased remarkedly,the ratio of HLD/TC increased remarkably,the the extent of aortic atherosclerosis and the atherosclerotic lesion lightened obviously.Conclusion:Laminaria Japonica Polysaccharides can effectively decrease the serum lipid and prevent the formation of atherosclerosis.