结核病治愈后抗结核抗体在体内持续时间的临床观察

目的　探讨结核病治愈后抗结核抗体在体内持续的时间。方法 ELISA法以PPD为包被抗原,每隔3个月检测治愈时血清抗结核抗体呈阳性的肺结核病人血清抗结核抗体1次,连续18个月。结果 每隔3个月抗结核抗体阳性人数逐渐下降,12个月时下降最明显,从9个月时的109人(63.0%)下降到21人(12.1%),与健康对照组间差异显著(P<0.05);15个月时阳性人数11人(6.4%),与健康对照组间差异不显著(P>0.05)。结论 肺结核病治愈后抗结核抗体呈阳性的病人其特异性抗体阳性持续时间一般为12～15个月,Ⅳ型结核治疗前病灶范围广,治愈后以增殖性病灶为主的患者持续的时间较长。

The clinical observation of the present duration of anti TB-IgG in the cured tuberculosis patients

Objective To observe the present duration of the anti TB IgG in the serum in cured tuberculosis patients.Methods The anti TB IgG in the serum in cured tuberculosis patients had been tested by ELISA in which PPD acts as the coated antigen every three months for 18 months.Results The number of positive patients decreased gradully.The decreasing rate was the greatest from 109 patients in the 9th month (63.0%) to 21 patients in the 12th month (12.1%).The number of positive patients in the 12th month was much more than that of healthy control ( P< 0.05).The number of positive patients in the 15th month was 11(6.4%) and no significant difference from the health control ( P> 0.05).Conclusion The present duration of anti TB IgG in the cured pulmonary tuberculosis patients was about 12 months to 15 months.On the chronic fibrotic caritary tuberculosis patients,before the treatment its focus scope was wide,after cured,the present duration of the patients with the proliferativeform as the major focus was longer.