Myoglobinopathy as a cause of acute interstitial nephritis

The course of the acute renal failure (ARF) was studied in 3 patients with rhabdomyolysis (1 with the position compression syndrome, 1 with march myoglobinuria, and 1 with chronic recurrent rhabdomyolysis). The ARF syndromes were revealed in 2 patients 5-7 days after onset of the disease; in 1 patient (chronic recurrent rhabdomyolysis), ARF recurred. This suggests that the patients developed acute interstitial nephritis (AIN) Prolonged myolytic conditions due to ill-timed initiation of treatment led to the fact that AIN was complicated by ARF in 2 patients, and 1 patient with chronic myopathy had an "immune readiness" for myoglobin to affect the kidneys, which also resulted in ARF. It was stressed that the methods of extracorporeal detoxification (hemodialysis, hemosorption) were highly effective in treating AIN and ARF.