| 紫外双波长、系数倍率法测定头孢吡肟与甲硝唑配伍的稳定性 |
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| 引用本文： | 罗宇芬,叶萍,赵珊.紫外双波长、系数倍率法测定头孢吡肟与甲硝唑配伍的稳定性[J].中国新药与临床杂志,2001,20(3):194-195. |
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| 作者姓名： | 罗宇芬 叶萍 赵珊 |
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| 作者单位： | 广东省人民医院 药学部, |
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| 摘 要： | 目的 :考察头孢吡肟与 0 .5%甲硝唑配伍的稳定性。方法 :用紫外双波长、系数倍率法分别测定头孢吡肟与甲硝唑的含量。结果 :在 0 ,1,2 ,4 ,6h内 ,2药合用的含量、pH及外观基本不变。该方法的平均回收率头孢吡肟为 (10 0 .9± 0 .4 ) % (n =5) ,甲硝唑为 (99.8± 0 .6 ) % (n =5)。结论 :2种药物配伍 6h内基本稳定。用双波长、系数倍率法分别测定其稳定性 ,方法简便、准确、实用性广。
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| 关 键 词： | 分光光度法 头孢吡肟 甲硝唑 |
| 文章编号： | 1007-7669(2001)03-0194-02 |
Dual wavelength
spectrophotometry and K-ratio spectrophotometry in determining compatible stability of
cefepime with metronidazole |
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| LUO Yu-fen,YE Ping,Zhao Shan.Dual wavelength
spectrophotometry and K-ratio spectrophotometry in determining compatible stability of
cefepime with metronidazole[J].Chinese Journal of New Drugs and Clinical Remedies,2001,20(3):194-195. |
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| Authors: | LUO Yu-fen YE Ping Zhao Shan |
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| Abstract: | AIM: To study the compatible stability of cefepime with 0.5% metronidazole injection. METHODS: Dual wavelength spectrophotometry and K-ratio spectrophotometry were described for the determination of cefepime with metronidazole injection during 6 h. RESULTS: There was no evident variation in content during 6 h at room temperature. The average recovery rates of cefepime and metronidazole were (100.9±0.4)% and (99.8±0.6)% (n=5). CONCLUSION: The compatiblity of cefepime with metronidazole injection is stable. The method of using dual wavelength spectrophotometry and K-ratio spectrophotometry to determine the compatible stability of cefepime with metronidazole is simple, accurate and usable. |
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| Keywords: | spectrophotometry cefepime metronidazole [ |
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