Innovative non-animal testing strategies for reproductive toxicology: the contribution of Italian partners within the EU project ReProTect |
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Authors: | Lorenzetti Stefano Altieri Ilaria Arabi Sabina Balduzzi Donatella Bechi Nicoletta Cordelli Eugenia Galli Cesare Ietta Francesca Modina Silvia C Narciso Laura Pacchierotti Francesca Villani Paola Galli Andrea Lazzari Giovanna Luciano Alberto Maria Paulesu Luana Spanò Marcello Mantovani Alberto |
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Affiliation: | Dipartimento di Sanità Pubblica Veterinaria e Sicurezza Alimentare, Istituto Superiore di Sanità, Rome, Italy. stefano.lorenzetti@iss.it |
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Abstract: | Reproductive toxicity, with its many targets and mechanisms, is a complex area of toxicology; thus, the screening and identification of reproductive toxicants is a main scientific challenge for the safety assessment of chemicals, including the European Regulation on Chemicals (REACH). Regulatory agencies recommend the implementation of the 3Rs principle (refinement, reduction, replacement) as well as of intelligent testing strategies, through the development of in vitro methods and the use of mechanistic information in the hazard identification and characterization steps of the risk assessment process. The EU Integrated Project ReProTect (6th Framework Programme) implemented an array of in vitro tests to study different building blocks of the mammalian reproductive cycle: methodological developments and results on male and female germ cells, prostate and placenta are presented. |
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