| 核素乏氧显像在肿瘤放射治疗中的应用 |
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| 引用本文： | 杜雪梅,张延军. 核素乏氧显像在肿瘤放射治疗中的应用[J]. 国际放射医学核医学杂志, 2008, 32(2): 96-98 |
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| 作者姓名： | 杜雪梅 张延军 |
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| 作者单位： | 116011 大连, 大连医科大学附属第一医院核医学科 |
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| 摘 要： | 核素乏氧显像是一种可以为肿瘤乏氧程度提供定性及定量信息的显像,方法简便、安全、无创伤性。常用的乏氧组织显像剂有硝基咪唑类和非硝基咪唑类,前者进入细胞后,被还原的有效基团(-NO2)在乏氧细胞中不能再氧化而滞留于肿瘤细胞中,后者在乏氧组织中的滞留机制因显像剂的不同而不同。运用核素乏氧显像了解肿瘤组织的乏氧状态,对临床制定合理的放疗方案、评估放疗疗效有重要意义。
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| 关 键 词： | 细胞低氧 放射肿瘤学 乏氧显像 |
| 收稿时间： | 2007-06-15 |
Clinical application of nuclear hypoxia imaging on oncology radiation therapy |
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| DU Xue-mei,ZHANG Yan-jun. Clinical application of nuclear hypoxia imaging on oncology radiation therapy[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2008, 32(2): 96-98 |
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| Authors: | DU Xue-mei ZHANG Yan-jun |
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| Affiliation: | Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China |
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| Abstract: | Nuclear hypoxia imaging is a convenient and safe method which can provide qualitative and quantitative information of oncology hypoxic degree.The commonly used imaging agent have two categories.Nitroimidazole agent,which effective group(-NO2)reducted in the hypoxia cell can not be reoxidized and be detained in it.Nonitroimidazole agent,which imaging mechanisms are different according to different agents.This technology is useful to formulate reasonable radiotherapy plan and evaluate radiotherapy effect. |
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| Keywords: | Cell hypoxia Radiation oncology Hypoxia imaging |
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