| (E)-4-芳酰氧基苯基丁烯-3-酮-2衍生物的合成及生物活性 |
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| 引用本文： | 刘鹰翔,马玉卓,江涛. (E)-4-芳酰氧基苯基丁烯-3-酮-2衍生物的合成及生物活性[J]. 中国药物化学杂志, 2000, 10(4): 242-246 |
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| 作者姓名： | 刘鹰翔 马玉卓 江涛 |
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| 作者单位： | 广东药学院药学系!广州510224(刘鹰翔，马玉卓，江涛)，沈阳药科大学制药系!沈阳110015(计志忠) |
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| 摘 要： | 设计合成了 11个 (E) 3 甲氧基 4 芳酰氧基苯基丁烯 3 酮 2衍生物 .其中 10个目标物未见文献报道 .体内药理筛选结果表明 ,部分目标化合物具有不同程度的抗炎活性和抗血小板聚集活性 .
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| 关 键 词： | (E)-4-芳酰氧基苯基丁烯-3-酮-2 衍生物 抗炎 抗血小板聚集 |
| 修稿时间： | : |
Synthesisand Biological Activities of (E)-4-Aryloxyphenyl-3-buten-2-ones Derivatives |
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| Liu Yingxiang,Ma Yuzhuo,Jiang Tao,Ji Zhizhong. Synthesisand Biological Activities of (E)-4-Aryloxyphenyl-3-buten-2-ones Derivatives[J]. Chinese Journal of Medicinal Chemistry, 2000, 10(4): 242-246 |
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| Authors: | Liu Yingxiang Ma Yuzhuo Jiang Tao Ji Zhizhong |
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| Abstract: | In order to search for novel antiinflammatory agents and platelet aggregation inhibitors,eleven of ( E ) 4 aryloxyphenyl 3 buten 2 ones derivatives were designed and synthesized.Ten of them have not been reported before in literature except (9).Some of the target compounds possessed good antiinflammatory activities and platelet aggregation inhibition. |
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| Keywords: | aryloxyphenyl 3 buten 2 one derivatives antiinflammatory activity anti aggregation activity |
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