| 弥漫性大B细胞淋巴瘤临床病理分析 |
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| 引用本文： | 田秀春,李百周,徐天蓉. 弥漫性大B细胞淋巴瘤临床病理分析[J]. 江苏大学学报(医学版), 2002, 12(6): 569-570 |
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| 作者姓名： | 田秀春 李百周 徐天蓉 |
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| 作者单位： | 1. 江苏省苏北人民医院病理科,江苏,扬州,225001
2. 南京医科大学第一附属医院病理科,江苏,南京,210029 |
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| 摘 要： | 目的：研究弥漫性大B细胞淋巴瘤（DLBCL）临床病理特点。方法：在光镜下对DLBCL分型，用免疫组化ABC法研究DLBCL的免疫表型特点，使用的抗体有CD20、CD79、CD10、CD45RO、CD30、CD68、CD43、CD5、bcl-2、EMA、CK、S－100等，结果：根据不同的形态学特点可将DLBCL分为以下几种亚型；中心母细胞性13例、免疫母细胞性3例，浆母细胞性1例，B间变性大细胞淋巴瘤2例，大多叶核淋巴瘤1例和富于组织细胞和（或）T细胞的大B细胞淋巴瘤3例。一般均表达B细胞相关抗原，有4例表达T相关标记CD43。结论：DLBCL具有异质性的一组淋巴瘤，具有较宽的细胞谱系，掌握其形态学特点对于正确诊断具有重要意义。
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| 关 键 词： | 病理分析 淋巴瘤 大细胞 免疫组织化学 诊断 鉴别 |
| 文章编号： | 1671-7783(2002)06-0569-02 |
| 修稿时间： | 2002-09-11 |
A Clinicopathological Study of Diffuse Large B-cell Lymphoma |
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| TIAN Xiu-chun,LI Bai-zhou,XU Tian-rong. A Clinicopathological Study of Diffuse Large B-cell Lymphoma[J]. Journal of Jiangsu University Medicine Edition, 2002, 12(6): 569-570 |
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| Authors: | TIAN Xiu-chun LI Bai-zhou XU Tian-rong |
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| Affiliation: | TIAN Xiu-chun1,LI Bai-zhou2,XU Tian-rong2 |
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| Abstract: | Objective:To study the clinicopathological characteristics of Diffuse large B-cell lymphoma(DLBCL).Methods:Based on the morphology,DLBCL could be divided into different subtypes. Imuno-histochemistry was performed in paradin sections,using the antibodies of CD20,CD79,CD3,CD68,CD43,CD10,CD5,CD30,CK, S-100, and EMA.Results:Group DLBCL can be subdivided as follows:13 cases of centroblast, 3 cases of immunoblast, 1 case of plasmoblast, 2 cases of B anaplastic lymphma and 3 cases of histiocyte or large B cell lymphoma with T cells and 1 case of multilobulated lymphoma. Most cases express the Pan-B markers, few cases can express the T cell marker CD43.Conclusion:DLBCL is a group of heterogenious lymphoma with a wide cellular spectrum. The knowledge of the morphology is important in correct diagnosis. |
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| Keywords: | Lymphoma Large cell Immunohistochemistry Diagnosis Differential diagnosis |
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