Univalent fragments of antibody: a study by electron microscopy |
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| Authors: | J D Almeida B Cinader D Naylor |
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| Affiliation: | 1. Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;2. Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;3. Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands |
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| Abstract: | Univalent fragments, fractions I and II, of polyoma virys antibody, obtained by papain digestion, followed by chromatography, were examined, after negative staining, in the electron microscope. The mean length of the univalent fragments was 70 Å and the estimated maximum length was 90 Å. Univalent fragments were often seen attached to the virus in V-formation; the width of fragments so arranged was significantly smaller than that of fragments attached randomly. Divalent antibody can also, though rarely, be seen in V-formation. The width of divalent antibody, so arranged, is also significantly smaller than that of the unselected divalent antibody molecules. |
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