All-Trans Retinoic Acid as an Alternative to Chemotherapy in the Treatment of Acute Promyelocyte Leukemia |
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| Authors: | Thomas Kü hne Paul Imbach Erich Signer Bruno Osterwalder |
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| Institution: |
a University Children's Hospital Basel, Basel, Switzerland
b F. Hoffmann-La Roche Ltd., Basel, Switzerland |
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| Abstract: | A 12-year-old girl with acute promyelocytic leukemia has been treated with conventional chemotherapy. The patient remained in complete remission for a year when the first bone marrow relapse occurred. Since reinduction chemotherapy was rejected by the parents, an alternative treatment with oral all-trans retinoic acid was administered. A second complete remission was achieved within 100 days. After 14 months a second bone marrow relapse occurred. AM-trans retinoic acid and the combination with interferon-a failed. |
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| Keywords: | acute promyelocyte leukemia all-trans retinoic acid |
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