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Retinoic acid enhances the growth of only one subpopulation of granulomonocyte precursors |
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| Authors: | M Aglietta W Piacibello F Sanavio A Visconti F Gavosto |
| Abstract: | The effect of various concentrations of retinoic acid on the growth of committed granulomonopoietic precursors (CFU-GM) was studied on semisolid agar cultures. Retinoic acid increased the growth of day 14 CFU-GM but had no significant effect on day 7 CFU-GM. Since the latter are believed to represent the progeny of day 14 CFU-GM it is suggested that the effect of retinoic acid is confined to the early stages of granulomonocytic differentiation. |
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