| 肝细胞癌组织中HSP27、VEGF的表达变化及意义 |
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| 引用本文： | 郭威,陈谦,李淑群,喻亚群.肝细胞癌组织中HSP27、VEGF的表达变化及意义[J].山东医药,2011,51(30):13-14. |
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| 作者姓名： | 郭威 陈谦 李淑群 喻亚群 |
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| 作者单位： | 桂林医学院附属医院,广西,桂林,541001 |
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| 基金项目： | 广西医疗卫生重点科研课题资助项目 |
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| 摘 要： | 目的观察肝细胞癌（HCC）组织中热休克蛋白27（HSP27）和血管内皮生长因子（VEGF）的表达变化,并探讨其意义。方法采用免疫组化法检测68例HCC组织及癌旁组织中的HSP27、VEGF。结果 HCC组织中HSP27、VEGF阳性表达率分别为75.0%、72.0%,癌旁组织中分别为61.8%、36.8%,两者比较,P均〈0.05。HCC组织中,HSP27表达与乙肝表面抗原（HBsAg）阳性、淋巴结转移、肿瘤分化程度有关（P均〈0.05）,VEGF表达与肿瘤直径、淋巴结转移有关（P均〈0.05）;HCC组织中,HSP27与VEGF的表达呈正相关（r=0.248,P均〈0.05）。结论 HCC组织中HSP27、VEGF表达均升高;二者在HCC发生发展中具有重要作用,检测HSP27、VEGF对HCC的预后判断有一定参考价值。
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| 关 键 词： | 肝肿瘤 肝细胞癌 热休克蛋白 血管内皮生长因子 |
The change of expression of HSP27, VEGF in hepatocellular carcinoma and its significance |
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| GUO Wei,CHEN Qian,LI Shu-qun,YU Ya-qun.The change of expression of HSP27, VEGF in hepatocellular carcinoma and its significance[J].Shandong Medical Journal,2011,51(30):13-14. |
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| Authors: | GUO Wei CHEN Qian LI Shu-qun YU Ya-qun |
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| Institution: | GUO Wei,CHEN Qian,LI Shu-qun,YU Ya-qun(Affiliated Hospital of Guilin Medical College,Guilin,541001,P.R.China) |
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| Abstract: | Objective To observe the change of expression of heat shock protein 27(HSP27) and vascular endothelial growth factor(VEGF) in hepatocellular carcinoma(HCC) tissue and investigate its significance.Methods The expression of HSP27 and VEGF were determined with immunohistochemistry in cancerous and adjacent tissues from 68 cases of HCC.Results Positive expression rate of HSP27,VEGF in HCC tissue were 75.0%,72.0%,with 61.8%,36.8% in cancer tissue(all P<0.05).Expression of HSP27 was positively correlated with sur... |
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| Keywords: | liver neoplasms hepatocellular carcinoma heat shock protein 27 vascular endothelial growth factor |
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