| HPLC法测定盐酸普萘洛尔片的含量 |
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| 引用本文： | 赵纯玉,王玲,易燕群.HPLC法测定盐酸普萘洛尔片的含量[J].首都医药,2011(18):59-60. |
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| 作者姓名： | 赵纯玉 王玲 易燕群 |
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| 作者单位： | 广西桂林食品药品检验所,541002 |
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| 摘 要： | 目的建立测定盐酸普萘洛尔片含量的高效液相色谱法。方法采用SHIMADZU Shim-pack VP-ODS C18色谱柱(250mm×4.6mm,5μm),以甲醇-含0.1%庚烷磺酸钠的0.05mol/L磷酸二氢钾溶液(57∶43)为流动相,流速为1.0mL·min-1,检测波长为290nm。结果盐酸普萘洛尔在50.17～501.7μg/ml范围内与峰面积呈良好的线性关系,r=0.9999(n=6),平均加样回收率为99.43%,RSD为1.2%(n=9)。结论该方法简便、准确,专属性强,重现性好,可用于盐酸普萘洛尔片含量测定。
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| 关 键 词： | 高效液相色谱法 盐酸普萘洛尔片 含量测定 |
Determination of Propranolol Hydrochloride Tablets by HPLC |
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| Zhao Chunyu,Wang Ling,Yi Yanqun.Determination of Propranolol Hydrochloride Tablets by HPLC[J].Capital Medicine,2011(18):59-60. |
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| Authors: | Zhao Chunyu Wang Ling Yi Yanqun |
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| Institution: | Guangxi Guilin Institute for Food and Drug Control(541002)Zhao Chunyu Wang Ling Yi Yanqun |
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| Abstract: | Objective To establish the determination method of Propranolol Hydrochloride Tablets by HPLC.Method The quantitative determination was performed on a SHIMADZU Shim-pack VP-ODS C18 column（250mm×4.6mm,5μm）.using methanol：0.05mol/L potassium dihydrogen phosphate containing 0.1% sodium heptanesulfonate solution as mobile phase （57∶33） with a flow rate of 1.0mL·min^-1.And the UV detective wavelength was set 290nm.Result The method showed a good linear relationship within the range of 50.17ug/ml～501.7ug/ml, r=0.9999（n=6）.The average recovery was 99.43%, RSD =1.2% （n=9）.Conclusion The method is simple, accurate, reliable, reproducible and selective and could be used for quantitative determination of Propranolol Hydrochloride Tablets. |
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| Keywords: | HPLC Propranolol hydrochloride Determination |
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