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HPLC法测定盐酸普萘洛尔片的含量
引用本文:赵纯玉,王玲,易燕群. HPLC法测定盐酸普萘洛尔片的含量[J]. 首都医药, 2011, 0(18): 59-60
作者姓名:赵纯玉  王玲  易燕群
作者单位:广西桂林食品药品检验所,541002
摘    要:目的建立测定盐酸普萘洛尔片含量的高效液相色谱法。方法采用SHIMADZU Shim-pack VP-ODS C18色谱柱(250mm×4.6mm,5μm),以甲醇-含0.1%庚烷磺酸钠的0.05mol/L磷酸二氢钾溶液(57∶43)为流动相,流速为1.0mL·min-1,检测波长为290nm。结果盐酸普萘洛尔在50.17~501.7μg/ml范围内与峰面积呈良好的线性关系,r=0.9999(n=6),平均加样回收率为99.43%,RSD为1.2%(n=9)。结论该方法简便、准确,专属性强,重现性好,可用于盐酸普萘洛尔片含量测定。

关 键 词:高效液相色谱法  盐酸普萘洛尔片  含量测定

Determination of Propranolol Hydrochloride Tablets by HPLC
Zhao Chunyu,Wang Ling,Yi Yanqun. Determination of Propranolol Hydrochloride Tablets by HPLC[J]. Capital Medicine, 2011, 0(18): 59-60
Authors:Zhao Chunyu  Wang Ling  Yi Yanqun
Affiliation:Guangxi Guilin Institute for Food and Drug Control(541002)Zhao Chunyu Wang Ling Yi Yanqun
Abstract:Objective To establish the determination method of Propranolol Hydrochloride Tablets by HPLC.Method The quantitative determination was performed on a SHIMADZU Shim-pack VP-ODS C18 column(250mm×4.6mm,5μm).using methanol:0.05mol/L potassium dihydrogen phosphate containing 0.1% sodium heptanesulfonate solution as mobile phase (57∶33) with a flow rate of 1.0mL·min^-1.And the UV detective wavelength was set 290nm.Result The method showed a good linear relationship within the range of 50.17ug/ml~501.7ug/ml, r=0.9999(n=6).The average recovery was 99.43%, RSD =1.2% (n=9).Conclusion The method is simple, accurate, reliable, reproducible and selective and could be used for quantitative determination of Propranolol Hydrochloride Tablets.
Keywords:HPLC  Propranolol hydrochloride  Determination  
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