| 宫颈癌组织中B7-H3蛋白的表达变化及其与HPV感染的关系 |
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| 引用本文： | 蔡惠芬,史进方,顾国浩,卢春冬,任玉香,吴凤英.宫颈癌组织中B7-H3蛋白的表达变化及其与HPV感染的关系[J].山东医药,2011,51(30):4-5. |
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| 作者姓名： | 蔡惠芬 史进方 顾国浩 卢春冬 任玉香 吴凤英 |
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| 作者单位： | 1. 第三军医大学附属第一医院西南医院,重庆,400038
2. 苏州市苏州大学附属第一医院 |
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| 摘 要： | 目的观察宫颈癌组织中的B7家族同族3（B7-H3）蛋白的表达变化,探讨其与人乳头瘤病毒（HPV）感染的关系。方法采用免疫组化SP法检测50例宫颈癌组织肿瘤细胞和血管内皮细胞（宫颈癌组）中及15例子宫肌瘤组织（对照组）中的B7-H3蛋白。采用人乳头状瘤病毒核酸扩增分型检测试剂盒检测两组HPV感染情况。结果宫颈癌组肿瘤细胞B7-H3蛋白阳性41例,内皮细胞B7-H3蛋白阳性为24例;对照组宫颈组织细胞B7-H3蛋白阳性为3例,内皮细胞中无B7-H3表达,两组相比,P均〈0.05。宫颈癌组中HPV感染25例;对照组中无HPV感染者。宫颈癌组肿瘤细胞及血管内皮细胞中B7-H3蛋白表达与HPV感染呈正相关（r分别为0.364 4、0.400 3,P均〈0.05）。结论宫颈癌肿瘤细胞及血管内皮细胞中B7-H3呈高表达,且与HPV感染有关。
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| 关 键 词： | 宫颈肿瘤 B7家族同族 人乳头瘤病毒 |
Expression of B7-H3 in cervical cancer tissues and its relationship with HPV infection |
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| CAI Hui-fen,SHI Jin-fang,GU Guo-hao,LU Chua-dong,REN Yu-xiang,WU Feng-ying.Expression of B7-H3 in cervical cancer tissues and its relationship with HPV infection[J].Shandong Medical Journal,2011,51(30):4-5. |
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| Authors: | CAI Hui-fen SHI Jin-fang GU Guo-hao LU Chua-dong REN Yu-xiang WU Feng-ying |
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| Institution: | CAI Hui-fen1,SHI Jin-fang,GU Guo-hao,LU Chun-dong,REN Yu-xiang,WU Feng-ying(1 Southwest Hospital,Third Military Medical University,Chongqing 400038,P.R.China) |
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| Abstract: | Objective To observe the change of the expression of B7 family with the family 3(B7-H3)in cervical cancer tissue,and to explore the relationship with HPV infection.Methods The expression of B7-H3 protein in 50 cases of cervical cancer tumor cells and endothelial cells(cervical cancer group) and 15 cases of uterine fibroids(control group) tissue were detected by immunohistochemical SP method.Human papilloma virus nucleic acid amplification type detection kit was used to HPV infection detecting.Results In cer... |
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| Keywords: | cervical neoplasms B7 family with the family human papillomavirus |
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