| 缬草属植物特征性化合物缬草烯酸研究进展 |
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| 引用本文： | 左长英,闫智勇. 缬草属植物特征性化合物缬草烯酸研究进展[J]. 中国实验方剂学杂志, 2010, 16(14): 225-228 |
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| 作者姓名： | 左长英 闫智勇 |
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| 作者单位： | 西南交通大学生命科学与工程学院,成都,610031 |
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| 基金项目： | 国家科技重大专项"十一五"计划项目，中央高校基本科研业务费专项资金，成都市"十一五"重大科技专项，四川省中医药管理局科研课题 |
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| 摘 要： | 缬草烯酸valerenic acid是败酱科Valerianaceae缬草属Valeriana植物的特征化合物,是缬草属植物中枢抑制等作用的主要活性成分。最近研究表明,缬草烯酸是通过影响γ-氨基丁酸(GABAA)受体、5-羟色胺(5-HT)受体、核因子(NF-κB)等发挥其药理活性的。本文对缬草烯酸的分离和含量测定、药理药效及药代动力学3个方面进行了分析综述,以期为缬草烯酸的进一步研究提供参考。
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| 关 键 词： | 缬草属 缬草烯酸 综述 |
| 收稿时间： | 2010-06-02 |
Progress in Research on Valerenic Acid-a Key Marker Compound of Valerian |
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| ZUO Chang-ying and YAN Zhi-yong. Progress in Research on Valerenic Acid-a Key Marker Compound of Valerian[J]. China Journal of Experimental Traditional Medical Formulae, 2010, 16(14): 225-228 |
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| Authors: | ZUO Chang-ying and YAN Zhi-yong |
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| Affiliation: | School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China;School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China |
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| Abstract: | Valerenic acid is a key marker compound of valerian of Valerianacea,which also is one of the main active constituents of its central inhibiting effects.Recent studies show that valerenic acid has pharmacological effects probably through acting on GABAA receptor,5-HT receptor and NF-kappaB.In this paper the research progress of the extraction and content determination,pharmacological action,pharmacokinetics and pharmacodynamics of valerenic acid were involved,which will offer references for further study of Valerenic acid. |
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| Keywords: | valerian valerenic acid review articles |
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