老年糖尿病患者并发脑卒中事件的相关因素分析

目的 探讨老年2型糖尿病脑卒中发病的相关危险因素。方法 对88例老年2型糖尿病患者进行为期5年随访,并对卒中发病的相关因素进行cox回归分析。结果 88例患者随访期间,19例发生急性脑卒中,其中缺血性脑卒中占89.5％.出血性脑卒中占10.5％,糖尿病合并高血压和糖尿病合并冠心病患者较无相应合并症者脑卒中发病率均明显增高(P<0.05和P<0.01)。单因素cox回归分析显示:糖尿病合并高血压、冠心病、高胆固醇血症与脑卒中发病明显相关。调整了其他危险因素的作用后,多因素cox回归分析表明,糖尿病合并高血压及冠心病对脑卒中发病危险性的作用依然存在,而高胆固醇血症的作用消失。结论 老年2型糖尿病患者易于并发脑卒中,糖尿病合并高血压及冠心病为脑卒中发病独立危险因素,而高胆固醇血症可增加脑卒中发病危险性。

Analysis of the related factors of senile type 2 diabetes mellitus associated with cerebral stroke

Objective To investigate the associated risk factors of senile type 2 diabetes mellitus (DM) with cerebral stroke.Methods A 5 years follow - up performing to 88 cases of diabetes mellitus patients and the cox regression analysis method were carried out to analysis the related factors of stroke.Results 19 cases of acute stroke occurred in the courts of follow- up, cerebral arterial thrombosis were 17cases(89.5%), hemor-rhagic stroke were 2 cases (10.5%). The incidence rate stroke was significantly higher in type 2 diabetes patients with hypertenion and coronary heart diseases(CHD) than in simple diabetes(P < 0.05).The result of univariate cox regression analysis showed:increased duration of DM, hypertension in DM,CHD in DM and hypercholesteraemia were closely related with stroke. The increased duration of DM, hypertension in DM and CHD in DM remained significant even after adjusted the relative risk factors in multivecriate analysis: the effect of hypercholesteraemia was disappear. Conclusion Senile type 2 diabetes mellitus patients are prone to associated wiht stroke, increased duration of DM, hypertemsion in DM and CHD in DM are the major independent risk factors for stroke, hyperlipidemia can increase risk of stroke.