| 月见草油和二高-r-亚麻酸抑制血小板聚集和血栓素A_2合成作用的研究 |
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| 引用本文： | 傅方浩,吴大勇,谷月卿,刘银燕,陈滴,杨晓红.月见草油和二高-r-亚麻酸抑制血小板聚集和血栓素A_2合成作用的研究[J].吉林大学学报(医学版),1987(1). |
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| 作者姓名： | 傅方浩 吴大勇 谷月卿 刘银燕 陈滴 杨晓红 |
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| 作者单位： | 白求恩医科大学生理教研室
(傅方浩，吴大勇)，白求恩医科大学药物研究室
(谷月卿，刘银燕，陈滴)，白求恩医科大学药物研究室(杨晓红) |
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| 基金项目： | 中国科学院科学资金资助课题 |
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| 摘 要： | 本文报道了月见草油和二高—γ—亚麻酸有明显抑制血小板聚集和血小板合成血栓素A_2(TXA_2)的作用。以ID_(50)(抑制TxA_2合成50％的剂量计算,用兔血小板制备酶时两药剂量(月见草油按所含γ—亚麻酸量计算)、比值为7.7:1,用人血小板制备酶时其比值为7.5:1。同时也观察到HHT及HETE的变化。这为我国丰富的月见草资源作为防治血栓性心血管疾病的开发利用提供了理论依据。
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| 关 键 词： | 月见草油 二高—γ—亚麻酸 γ—亚麻酸 血栓素A_2 |
Inhibitory effect of Evening primose oil and Dihomo-gamma-linolenic acid on platelet aggregation and thromboxane biosynthesis |
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| Fu Fanghao,Gu Yueqing,Liu Yinyan,Chen Di,Yang Xiaohong and Wu Dayong.Inhibitory effect of Evening primose oil and Dihomo-gamma-linolenic acid on platelet aggregation and thromboxane biosynthesis[J].Journal of Jilin University: Med Ed,1987(1). |
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| Authors: | Fu Fanghao Gu Yueqing Liu Yinyan Chen Di Yang Xiaohong and Wu Dayong |
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| Abstract: | Our experiments proved that Evening primose oil (EPO)and Dihomo-gamma linolenic acid (DGLA) evidently inhibited platelet aggregation and thromboxane (TxA2) biosynthesis. Calculated according to ID50 (dose for 50% inhibition of TxA2),when ensyme from rabbit platelets was used,their ratio (ganuna-linolenic acid contained in EPO) was 7.7:1, when enzyme from human platelets was used, their ratio was 7.5:1. The changes in HHT and HETE were also observed. Our findings give a theoretical basis for exploitation and utilization of such rich resources of evening primose in OUT country for preventing and treating throm-botic cardiovascular diseases. |
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| Keywords: | Ereaing primose oil Dihomo-gamma-linolenic acid Gamma-linolenic acid Thromboxane |
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