CYP1A1 T6235C基因多态性与头颈恶性肿瘤易感性的Meta分析

目的 探讨Ⅰ相代谢酶细胞色素P450 1A1(CYP1A1) T6235C基因多态性与头颈恶性肿瘤易感性的关系.方法 检索PubMed、EMBASE、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)已发表的关于CYP1A1 T6235C基因多态性与头颈恶性肿瘤易感性的相关研究,筛选出符合条件的文献,应用Meta分析软件对各项研究进行异质性检验,计算合并OR值及其95％可信区间(CI),并行敏感度分析和发表偏倚的评估.结果 共16篇文献纳入本研究(病例组数2 754例；对照组数2 807例).Meta分析结果显示:CYP1A1 T6235C基因多态性与头颈恶性肿瘤有明显易感性(CC versus TT:OR =3.216,95％ CI 2.388～4.331；CC versus CT/TT:OR=2.496,95％ CI1.994～3.124;CC versus CT:OR=1.993,95％ CI 1.476 ～2.692; CC/CTversus TT:OR=1.573,95％ CI1.230～2.013).根据种族进行分层分析发现亚洲人群有明显易感性.结论 CYP1A1 T6235C基因多态性与头颈恶性肿瘤易感性间存在明显易感性.

Meta-analysis on CYP1A1 T6235C polymorphism and head and neck cancer susceptibility

Objective To investigate the association between polymorphism of CYP1A1 T6235C and susceptibility of head and neck cancer. Methods Studies on CYP1A1 T6235C and susceptibility of head and neck cancer were collected by PubMed, EMBASE, CBM and CNKI, et al. The pools ORs with 95% CI were calculated to assess the association strength between polymorphism of CYP1A1 T6235C and head and neck cancer risk using Meta methods. Sensitivity and publication bias were evaluated. Results Sixty studies with 2754 cases and 2807 controls were included. The pooled results indicated that the significant association of this polymorphism with head and neck cancer was found （ OR cc vs. rr = 3. 216, 95% CI 2.388 ~ 4.331 ; ORcc vs. CT/TT -~ 2. 496,95% CI 1. 994 ~ 3. 124 ; ORcc vs. cr = 1. 993, 95%CI 1. 476 - 2. 692; ORcc/cTv~. TT = 1. 573,95% CI 1. 230 ~ 2. 013 ）. A significant association was observed in subgroup analysis based on ethnicity, especially in Asian group. Condusions There was a significant association between CYP1A1 T6235C polymorphism and head and neck cancer susceptibility.