Expression of type C virus p30 in mouse cells infected with herpes simplex virus. |
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| Authors: | B Hampar J R Stephenson A Boyd J G Derge A Brown S Oroszlan |
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| Affiliation: | 1. Laboratory of DNA Tumor Viruses, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA;2. Laboratory of RNA Tumor Viruses, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA;3. Viral Oncology Program, NCI Frederick Cancer Research Center, P.O. Box B, Frederick, Maryland 21701, USA |
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| Abstract: | Expression of type C virus p30 in BALB/c and NIH Swiss mouse cells infected with live (productive infection) or uv-irradiated herpes simplex virus (uv-HSV) types 1 and 2 was studied by use of either immunofluorescent (FA) or radioimmunoassay (RIA) procedures. No evidence for enhanced expression of p30 was obtained with either of these procedures although activation of type C virus in uv-HSV-infected BALB/c cells was readily demonstrated at low frequencies (～10?4) by infectious center assay. While FA staining with rabbit anti-murine leukemia virus (MuLV) p30 serum was observed in mouse cells productively infected with HSV or infected with uv-HSV, this was shown to be nonspecific. It was concluded that activation of type C virus in uv-HSV-infected BALB/c cells does not occur in significantly more cells than detected by infectious center assay. |
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| Keywords: | Author to whom reprint requests should be addressed. |
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