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Immunohistochemical and morphometric investigations of the influence of botulinum toxin on the submandibular gland of the rat |
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| Authors: | M. Ellies R. Laskawi W. Götz C. Arglebe G. Tormählen |
| Affiliation: | Specialist in Otorhinolaryngology, Voice and Speech Disorders, Leipziger Strasse 115, D-34123 Kassel, Germany, DE Department of Otorhinolaryngology, University of G?ttingen, G?ttingen, Germany, DE Department of Histology, University of G?ttingen, G?ttingen, Germany, DE |
| Abstract: | Immunohistochemical methods were used to study the effects of botulinum toxin A on the concentration of acetylcholinesterase in the submandibular gland of the rat. The toxin was injected into the glands of healthy adult female Wistar rats and immunohistochemistry performed on the excised organs. Morphometric measurements were also carried out to study changes of cell morphology after local applications of botulinum toxin A. Compared with untreated glands or glands injected with saline there was a decrease of acetylcholinesterase in the glands treated with botulinum toxin. As the cholinergic pathway of the autonomic nervous system plays an important role in eliciting secretion from the salivary glands, inhibition of secretion by local application of botulinum toxin could be considered a therapeutic option for the treatment of various diseases affecting salivary gland function. Received: 7 May 1998 / Accepted: 20 August 1998 |
| Keywords: | Salivary glands Hypersalivation Cell morphology Chronic sialadenitis Botulinum toxin A |
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