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慢性乙型肝炎患者PD-1/PD-L1信号通路的免疫调节作用研究进展
引用本文:曹霖霖综述,张国梁审校. 慢性乙型肝炎患者PD-1/PD-L1信号通路的免疫调节作用研究进展[J]. 实用肝脏病杂志, 2015, 18(6): 682-686. DOI: 10.3969/j.issn.1672-5069.2015.06.032
作者姓名:曹霖霖综述  张国梁审校
作者单位:230031 合肥市 安徽中医药大学研究生学院
摘    要:程序性死亡分子-1(PD-1)是T淋巴细胞膜表面表达的负向协同刺激分子, 与其主要配体(PD-L1)形成通路后,可以减弱T淋巴细胞的免疫反应,甚至导致T淋巴细胞功能衰竭。PD-1/PD-L1信号通路在乙型肝炎病毒感染后的效应T细胞免疫耐受中具有重要作用,阻断该途径可能是抗病毒治疗的方向之一,具有良好的应用前景。

关 键 词:慢性乙型肝炎  程序性死亡分子-1/程序性死亡分子-1配体  T淋巴细胞  免疫调节  
收稿时间:2015-04-14

Immunoregulatory effect of PD-1/PD-L1 signaling pathway in chronic hepatitis B viral infection
Cao Linlin,Zhang Guoliang.. Immunoregulatory effect of PD-1/PD-L1 signaling pathway in chronic hepatitis B viral infection[J]. Journal of Clinical Hepatology, 2015, 18(6): 682-686. DOI: 10.3969/j.issn.1672-5069.2015.06.032
Authors:Cao Linlin  Zhang Guoliang.
Affiliation:Department of Infectious Diseases,First Affiliated Hospital,Anhui University of Traditional Chinese Medicine,Heifei 230031,China
Abstract:Programmed cell death-1(PD-1),as an inhibitory co-stimulatory molecule,is expressed on the surface of T lymphocyte membranes. After interacting with its main ligand,programmed death-1 ligand(PD-L1),PD-1 decreases immune response of T lymphocytes,and even damages the overall functioning of T lymphocytes. PD-1/PD-L1 signaling pathway plays an important role in the tolerance of T cell immune response triggered by hepatitis B virus infection. Studies indicate that blocking this pathway may provide an new insights into antiretroviral therapy,and might be a promising applications in clinical practice.
Keywords:Chronic Hepatitis B   PD-1/PD-L1   T lymphocytes   Immunomodulation  
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