活血化瘀药对腹膜透析腹膜高转运患者结局的影响

目的分析活血化瘀药对腹膜透析腹膜高转运患者结局的影响。方法采用随机数表法将我院2017年4月-2019年10月收治的78例腹膜透析腹膜高转运患者分为对照组(n=39)和观察组(n=39),对照组患者给予CAPD(连续性可携带式腹膜透析)模式治疗,观察组在对照组基础上施以活血化瘀类药物(灯盏花素注射液)治疗。观察并对比两组患者IL-6、hs-CRP、TNF-α水平以及RBP、PA水平变化。结果两组治疗前腹透Cer、KT/V、RBP、PA、hs-CRP水平差异无统计学意义(P>0.05);治疗15天后,观察组Cer和KT/V、RBP、PA水平相比照组较高,hs-CRP水平比对照组低,差异有统计学意义(P<0.05);观察组治疗后净超滤量低于对照组,差异有统计学意义(P<0.05)。结论采用活血化瘀类药物可以有效改善腹膜透析腹膜高转运患者的微炎症,降低净超滤量,改善结局。

Effect of Activating Blood Circulation and Removing Blood Stasis Drugs on Outcome of Patients with Peritoneal Dialysis and High Peritoneal Transport

Objective To analyze the effects of activating blood circulation and removing blood stasis drugs on the outcome of patients with high peritoneal dialysis during peritoneal dialysis.Methods A random number table was used to divide 78 patients with peritoneal dialysis and high peritoneal transport in our hospital from April 2017 to October 2019. The patients were divided into the control group( n = 39) and the observation group( n = 39). CAPD( continuous portable peritoneal dialysis)mode of treatment,the observation group based on the control group was treated with blood stasis drugs( breviscapine injection)treatment. Observe and compare the changes of IL-6,hs-CRP,TNF-α and RBP,PA levels in the two groups of patients.Results There was no significant difference in Cer,KT/V,RBP,PA,and hs-CRP levels between the two groups before treatment(P>0.05). After 15 days of treatment,the levels of Cer and KT/V,RBP,and PA in the observation group were compared. The group was higher,the hs-CRP level was lower than the control group,the difference was statistically significant(P<0.05);the net ultrafiltration amount in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The use of drugs for activating blood circulation and removing blood stasis can effectively improve the microinflammation,reduce the net ultrafiltration volume and improve the outcome in patients with peritoneal dialysis and high peritoneal transport.