磷酸化STAT3蛋白与胃癌患者预后及临床病理特征关系的Meta分析

目的系统评价磷酸化STAT3蛋白(p-STAT3)与胃癌患者预后及临床病理特征的相关性。方法检索从建库至2019年6月在PubMed、Embase、The Cochrance Library、万方、中国知网、维普等数据库公开发表的关于胃癌中p-STAT3蛋白表达与临床意义的研究,根据纳入及排除标准筛选文献,提取相关数据,采用Revman 5.3和Stata 12.0软件进行Meta分析。结果共纳入13篇文献,共1307例胃癌患者。Meta分析结果显示:p-STAT3蛋白高表达与胃癌患者的不良预后有关(HR=2.38,95%CI:1.89~3.01,P<0.00001),其与胃癌分化程度(OR=3.08,95%CI:1.92~4.93,P<0.00001)、TNM分期(OR=2.87,95%CI:1.75~4.71,P<0.0001)、淋巴结转移(OR=2.53,95%CI:1.35~4.73,P=0.004)、远处转移(OR=0.17,95%CI:0.09~0.36,P<0.00001)、浸润深度(OR=2.74,95%CI:1.66~4.53,P<0.0001)具有相关性,而与性别(OR=0.97,95%CI:0.74~1.27,P=0.82)、年龄(OR=0.75,95%CI:0.53~1.06,P=0.10)、肿瘤大小(OR=0.76,95%CI:0.55~1.05,P=0.10)均无相关性。结论p-STAT3蛋白与胃癌患者不良预后及胃癌分化程度、TNM分期、淋巴结转移、远处转移及肿瘤浸润深度密切相关,提示其对胃癌的发展起调控作用,可能作为预测胃癌的一个分子标志物。

Correlation of the expression of p-STAT3 protein with prognosis and clinicopathological characteristics in gastric cancer patients: a Meta-analysis

Objective To systematically evaluate the correlation of phosphorylated STAT3(p-STAT3)protein with prognosis and clinicopathological characteristics of gastric cancer patients.Methods The research on the expression and clinical significance of p-STAT3 protein in gastric cancer from database establishment to Jun.2019 in PubMed,Embase,The Cochrance Library,Wanfang,CNKI and VIP databases was retrieved,the literatures were screened according to inclusion and exclusion criteria and the relevant data were extracted.Revman 5.3 and Stata 12.0 software were used for the Meta-analysis.Results A total of 13 articles and 1307 patients with gastric cancer were included.The results of this Meta-analysis suggested that high expression of p-STAT3 protein was associated with poor prognosis in patients with gastric cancer(HR=2.38,95%CI:1.89-3.01,P<0.00001),and the expression of p-STAT3 protein in gastric cancer was associated with tumor differentiation degree(poorly vs well-moderately:OR=3.08,95%CI:1.92-4.93,P<0.00001),TNM stage(Ⅲ/ⅣvsⅠ/Ⅱ:OR=2.87,95%CI:1.75-4.71,P<0.0001),lymph node metastasis(present vs absent:OR=2.53,95%CI:1.35-4.73,P=0.004),distant metastasis(absent vs present:OR=0.17,95%CI:0.09-0.36,P<0.00001)and depth of invasion(T3/T4 vs T1/T2:OR=2.74,95%CI:1.66-4.53,P<0.0001),however,it was not related with gender(OR=0.97,95%CI:0.74-1.27,P=0.82),age(OR=0.75,95%CI:0.53-1.06,P=0.10)and tumor size(OR=0.76,95%CI:0.55-1.05,P=0.10).Conclusion The expression of p-STAT3 protein has significant correlation with poorer prognosis of gastric cancer patients,as well as with tumor differentiation degree,TNM stages,lymph node metastasis,distant metastasis and depth of invasion.Thus,it suggests that it may not only serve a biomarker for poor prognosis in gastric cancer,but also play a regulatory role in the development of gastric cancer.