恩替卡韦治疗乙型肝炎肝硬化伴肝源性糖尿病的临床疗效研究

目的探究恩替卡韦治疗乙型肝炎肝硬化伴肝源性糖尿病的临床疗效。方法选取该院于2017年1月—2019年2月收治的160例乙型肝炎肝硬化伴肝源性糖尿病患者作为该次的研究对象,采用随机数表法将其平均分为两组,对照组患者采取常规护肝及降糖药物治疗,观察组患者在常规药物治疗的基础上联合恩替卡韦进行治疗,治疗后对比两组患者的肝功能各项指标以及血糖水平改善情况。结果采用不同药物进行治疗后,观察组患者的谷丙转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清白蛋白(ALB)、总胆红素(TBIL)等各项肝功能指标均优于对照组,差异有统计学意义(P<0.05);观察组患者的空腹血糖、餐后2 h血糖以及糖化血红蛋白的水平均明显低于对照组,差异有统计学意义(P<0.05)。结论在对乙型肝炎肝硬化伴肝源性糖尿病患者进行治疗时,在常规药物治疗的基础上联合恩替卡韦进行治疗,能够有效改善患者的各项肝功能指标,具有更高的降糖效果,值得广大医院进行推广和研究。

Clinical Efficacy of Entecavir in the Treatment of Hepatitis B Cirrhosis with Hepatic Diabetes

Objective To investigate the clinical efficacy of entecavir in the treatment of hepatitis B cirrhosis with hepatic diabetes.Methods A total of 160 patients with hepatitis B cirrhosis and hepatic diabetes mellitus admitted to the hospital from January 2017 to February 2019 were enrolled in this study.The patients were divided into two groups by random number table method.The patients in the control group were treated with conventional liver and hypoglycemic drugs.The patients in the observation group were treated with entecavir on the basis of conventional drug treatment.After treatment,the liver function indexes and blood glucose levels were improved.Results After treatment with different drugs,the liver function indexes of alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum albumin(ALB)and total bilirubin(TBIL)were observed in the observation group.All were better than the control group,the difference was statistically significant(P<0.05);the fasting blood glucose,postprandial 2 h blood glucose and glycated hemoglobin levels in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with hepatitis B cirrhosis with hepatic diabetes,combined with entecavir on the basis of conventional drug therapy,can effectively improve the liver function indicators of patients,with higher hypoglycemic effect,which is worthy of promotion and research by the majority of hospitals.