泮托拉唑四联法不同疗程对胃溃疡合并糖尿病患者的疗效及复发率的影响研究

目的探讨泮托拉唑四联法不同疗程对胃溃疡合并糖尿病患者的疗效及复发率的影响。方法纳入50例2017年5月—2018年5月该院胃溃疡合并糖尿病患者开展研究,所有患者均采用泮托拉唑、克拉霉素、阿莫西林、果胶铋四联法治疗,按随机排列法选出25例列为对照组:1个疗程;剩余25例列为研究组:3个疗程;比较两组对临床疗效及复发率的影响。结果研究组总有效率为92.00%,高于对照组的76.00%,差异有统计学意义(P<0.05);两组治疗结束1个月后Hp阳性率差异无统计学意义(P>0.05),治疗结束1年后研究组Hp阳性率及复发率均低于对照组,差异有统计学意义(P<0.05);两组血糖水平对比,治疗前差异无统计学意义(P>0.05),治疗后,研究组空腹及餐后2 h血糖均低于对照组,差异有统计学意义(P<0.05)。结论在胃溃疡合并糖尿病患者的治疗中,泮托拉唑四联法3个疗程疗效优于1个疗程,可提高临床有效率,降低Hp阳性率及复发率,有效控制患者血糖水平,值得推广。

Effect of Pantoprazole Quadruple Therapy on the Efficacy and Recurrence Rate of Gastric Ulcer Patients with Diabetes Mellitus

Objective To investigate the effect of pantoprazole quadruple therapy on the efficacy and recurrence rate of patients with gastric ulcer and diabetes mellitus.Methods A total of 50 patients with gastric ulcer and diabetes mellitus were enrolled in the hospital from May 2017 to May 2018.All patients were treated with pantoprazole,clarithromycin,amoxicillin and pectin were randomly selected.Listed as the control group:1 course of treatment;the remaining 25 cases were included in the study group:3 courses;the effects of the two groups on clinical efficacy and recurrence rate were compared.Results The total effective rate of the study group was 92.00%,which was higher than 76.00%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in Hp positive rate after 1 month of treatment(P<0.05).The Hp positive rate and recurrence rate of the study group 1 year after the end of treatment.The blood glucose levels were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the two groups(P>0.05).After treatment,the blood glucose of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with gastric ulcer and diabetes,the pantoprazole quadruple method is better than one course of treatment,which can improve clinical efficiency,reduce Hp positive rate and recurrence rate,and effectively control blood glucose level of patients.It is worthy of promotion.