Animal experiments and clinical studies on intravascular lipid metabolism in relation to thyroid hormone status

Animal-experimental and clinical investigations concerning the intravasal lipid metabolism in disturbances of the thyroid hormones were performed. The results of these investigations show adverse effects of the thyroid hormones between man and rat with regard to the metabolism of lipoproteins rich in triglycerides. While in the clinical investigations performed an increase of the activity of the post-heparin lipase in hyperthyroidism of the type of Basedow's disease, connected with low triglyceride and VLDL levels in the serum was the result, in the animal experiment an opposite behaviour was established. Inverse relations were made evident also in hypofunction of the thyroid gland.