Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. |
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| Authors: | Matthew H T Bui David Seligson Ken-ryu Han Allan J Pantuck Frederick J Dorey Yunda Huang Steve Horvath Bradley C Leibovich Shefali Chopra Shu-Yuan Liao Eric Stanbridge Michael I Lerman Aarno Palotie Robert A Figlin Arie S Belldegrun |
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| Affiliation: | Department of Urology, University of California, Los Angeles, California 90095-1738, USA. |
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| Abstract: | PURPOSE: Metastatic renal cell carcinoma (RCC) has a poor prognosis and an unpredictable course. To date, there are no molecular markers which can reliably predict RCC outcome. We investigated whether a novel kidney cancer marker, carbonic anhydrase IX (CAIX), is associated with progression and survival. EXPERIMENTAL DESIGN: Immunohistochemical analysis using a CAIX monoclonal antibody was performed on tissue microarrays constructed from paraffin-embedded specimens from patients (N = 321) treated by nephrectomy for clear cell RCC. CAIX staining was correlated with response to treatment, clinical factors, pathologic features, and survival. RESULTS: CAIX staining was present in 94% of clear cell RCCs. Survival tree analysis determined that a cutoff of 85% CAIX staining provided the most accurate prediction of survival. Low CAIX (
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