电针对实验性脑梗塞时脑血流量的影响

<正> 脑血管疾病是严重危害人民健康的疾病之一,是老年人严重致残和死亡的重要原因。用针灸治疗脑血管疾病已有大量报道,取得明显疗效。为了探讨针刺治疗脑血管疾病的作用机制。我们采用结扎大脑中动脉造成脑梗塞的动物模型,观察电针对脑梗塞过程中脑血流的影响。方法采用健康杂种犬,体重14.82±0.67公斤,雌雄不拘,用戊巴比妥钠30毫克/公斤体重,在腹腔麻醉下切开气管并插管,联接3c-2型人工呼吸器维持正压呼吸,取左侧

EFFECT OF ELECTRO--ACUPUNCTURE ON THE CEREBRAL VOLUME OF BLOODFLOW DURING EXPERIMENTAL CEREBRAL INFARCTION

For stdying the mechanism of therapeutic effect on treating cerebral vessel diseases with acupuncture, the dogs were anesthetized with 30 mg/kg pentobarbital sodium and maintained with mechanical respiration The cere- bral infarction model of the animal was set up with partial craniectomy of parietal and temporal bone and occluding the middle cere bral artery (MCA). Carotid artery and vertebral artery were dissected. The vertebral artery was supplied with the blood from carotid. Cerebral volume of blood flow was recorded with MF-27 electromagnetic blood flow meter. Artery blood presstre was recorded and the blood of artery was obtained for analysis simultaneously. Acupuncture group(n=10) and control group (n=12)were recorded five times respectively. The values recorded 15 minutes after the ligation were used as the control. The weight of the brain was measured at the end of experiment. The results of experiment are as follows: 75 minutes after occlusion, comparing with the control the values of the ccrebral volume of blood flow of the acupuncture group reduced not remarkablly, there was significant difference between them (P<0.0l); the mean artery pressure (MAP) did not alter remarkablly; the resista- nce of the cerebral vessel (mmHg/ml/100gram/min, which equals MAP cerebral blood flow volume (ml/100g/min) increased retharkablly (P<0.05). Comparing with the value of control group, there was no remarkable difference in the practice measure valuer of the cerebral blood flow vo- lume, and the cerebral blood flow volume per one hundred grams brain tissues, MAP and the resistance and the decrease tendency of the cere- bral blood flow volume could be inhibited or alleviated by acupuncture. It was indicated that the cerebral vessel resistance could be decreased and the cerebral blood flow volume could be increased by acupuncture, so as to alleviate the brain tissues injury.