| 咪达普利、缬沙坦抑制动脉粥样硬化的作用及机制 |
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| 引用本文： | 周纪星,陈作元,马颍. 咪达普利、缬沙坦抑制动脉粥样硬化的作用及机制[J]. 中国现代医药杂志, 2008, 10(10) |
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| 作者姓名： | 周纪星 陈作元 马颍 |
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| 作者单位： | 山东省临沂市沂水中心医院心内科,276400 |
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| 摘 要： | 目的研究咪达普利，缬沙坦抑制动脉粥样硬化的作用及其机制。方法40只纯种大白兔随机分为4组。喂养8周后测定各组血清中总胴固醇（TC）、甘油三酯（TG）及低密度脂蛋白胆固醇（LDL），免疫组化观察粥样硬化斑块中STAT3、P21、CDK4的表达情况。结果高脂组、药物干预组血清TC、TG、LDL—C水平较对照组显著升高。STAT3、CDK4在药物干预组中表达较高脂组明显减少．而P21在药物干预组的表达较高脂组则明显升高。结论咪达普利、缬沙坦可明显抑制动脉粥样硬化的发生，其机制可能与抑制STAT3的信号传导和平滑肌增值有关。
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| 关 键 词： | 动脉粥样硬化 咪达普利 缬沙坦 平滑肌增殖 |
The effect of imidapril and valsartan on inhibiting the development of atherosclerosis and its mechanism |
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| Zhou Jixing,Chen Zuoyuan,Ma Ying. The effect of imidapril and valsartan on inhibiting the development of atherosclerosis and its mechanism[J]. Modern Medicine Journal of China, 2008, 10(10) |
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| Authors: | Zhou Jixing Chen Zuoyuan Ma Ying |
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| Affiliation: | Zhou Jixing,Chen Zuoyuan,Ma Ying.Department of Cardiology,YiShui Central Hospital,Sh,ong 276400 |
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| Abstract: | Objective To investigate the effect of imidapril and valsartan on inhibiting the development of atheroscle-rosis. Methods The rabbits were randomly divided into four groups. Blood samples were collected at the end of 8 weeks for examination of serum lipid levels and the expression of STAT3, P21, CDK4 were detected by immunohistochemistry. Results Rabbits fed with cholesterol-rich diet showed higher serum lipid levels than those fed with normal diet. The expression of STAT3, CDK4 in imidapril treated group a... |
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| Keywords: | Atherosclerosis Imidapril Valsartan Proliferation of vascular smooth muscle cells |
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