原因不明习惯性流产患者红细胞免疫功能的变化

目的:探讨原因不明习惯性流产与红细胞免疫功能的变化关系。方法:采用花环试验测定28例原因不明的早期习惯性流产患者红细胞免疫功能,观察免疫治疗前后免疫功能变化,以正常早孕、非早孕妇女为对照。结果:早期习惯性流产患者红细胞C_3b受体花环率(21.41％±6.2％)较正常早孕妇女(14.45％±4.82％)及正常未孕妇女(12.75％±4.27％)明显升高(P<0.01);早孕妇女与未孕妇女间红细胞C_3b受体花环率无明显差异(P>0.05);习惯性流产患者红细胞表面IC花环率(10.55％±4.12％)较正常早孕妇女(6.50％±3.12％)及正常未孕妇女(4.20％±2.50％)明显升高(P<0.01),而早孕妇女与未孕妇女间红细胞表面IC花环率也有明显差异(P<0.05)。免疫治疗后红细胞C_3b受体花环率(15.20％±4.86％)较治疗前明显降低(P<0.01);红细胞表面IC花环率(7.80％±3.50％)也有明显降低(P<0.01)。结论:早期习惯性流产患者体内红细胞免疫功能亢进或紊乱,红细胞免疫参与习惯性流产的发生、发展过程,免疫疗法可明显改善机体紊乱的红细胞免疫状态;红细胞免疫可作为免疫疗法临床疗效的监测指标。

Investigation of Erythrocyte Immune Function of Patients with Unclear Habitual Abortion

Objective: To study relation between the change of erythrocyte immune function and unclear habitual abortion. Method: To mensurate erythrocyte immune function of 28 patients with early unclear habitual abortion and observe it's change before and after treatment comparing with normal non - pregnant women and normal early - pregnant women. Results: Donee C3b rosette rate of the patients with early habitual abortion were 21. 41±6. 2% and were significantly higher than one of early -pregnant women (45%±4. 82% ) and one of normal non -pregnant women (12. 75 ±4. 275) (P <0. 01). Donee C3b ro-sette rate of early - pregnant women was not significantly different from one of non - pregnant women ( P > 0. 05 ) . At the same time, Epiderm IC rosette rate of women with habitual abortion( 10. 55±4. 12)% was higher than one of early - pregnant women (6. 50%±3. 12% ) and non - pregnant women (4. 20%±2. 50% ) (P < 0. 01). Epiderm IC rosette rate of early -pregnant women was remarkable different from one of non - pregnant. RC3b ( 15. 20%±4. 86% ) and RICR (7. 80%±3. 50% ) were decreased significantly after immunization therapy ( P < 0. 01) . Conclusion: The erythrocyte immune function disorder is an important factor that caused early habitual abortion. The immunization therapy can improved significantly disorder condition and is effective.