Factor VIII hyperactivity: an arterio-venous thrombogenic factor. Case report |
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Authors: | Bennani S L Vaquette B Pavin D Boulmier D Daubert J C Mabo P |
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Institution: | Département de cardiologie et maladies vasculaires, Centre cardio-pneumologique niveau 6, h?pital Pontchaillou, CHU, 35033 Rennes. |
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Abstract: | Thrombosis is the principal mechanism in vascular pathology, whether cerebral, coronary or peripheral. During the initial stages of infarction, coagulation contributes to vascular occlusion, the haemostatic factors playing a determining role in the development of atherothrombotic lesions. An increase in a coagulation protein, besides any lowering of anticoagulation protein levels, is a risk factor for thrombosis. Among these pro-coagulant factors, the pro-thrombogenic action of factor VIII has without doubt been studied the least. We report the case of a 62 year old patient with a personal and family history of many previous thrombotic episodes, both arterial and venous, in whom factor VIII hyperactivity was discovered after a myocardial infarction. This case underlines the association of the factor VIII complex with thrombosis, and its clinical repercussions, especially the incidence of coronary pathology. |
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