甘遂和低分子量肝素联合应用治疗重症急性胰腺炎的实验研究

目的 ： 探讨甘遂和低分子量肝素联合应用对重症急性胰腺炎治疗是否有协同作用。方法 ：分析比较假手术组（A组）、重症急性胰腺炎组（B组）、重症急性胰腺炎甘遂治疗组（C组）、重症急性胰腺炎低分子量肝素治疗组（D组）、重症急性胰腺炎甘遂和低分子量肝素联合治疗组（E组）各组血清TNF-α，IL-6水平和胰腺组织的TXB2/6-keto-PGF1α比值以及组织学检查结果。结果 ：C，D，E 3个治疗组血清TNF-α，IL-6水平和胰腺组织的TXB2/6-keto-PGF1α比值在6，12，24h各时点的值较B组低（ P <0.05或 P <0.01），而C，D，E 3个治疗组在各时间点无显著差异。组织学检查结果显示，A组胰腺的形态学正常;C，D，E 3组胰腺病理学改变轻于B组。结论 ：联合应用甘遂和低分子量肝素治疗SAP有效，但尚未发现甘遂和低分子量肝素的协同作用，亦未发现不利影响。

Experimental study of kansui root and LMWH combined therapy for severe acute pancreatitis

Abstract:Objective ：To investigate if there is a synergism of kansui root and low molecular weight heparin(LMWH) in combined treatment of SAP in rats. Methods ：SD rats were randomly divided into 5 groups:Sham group(A group), severe acute pancreatitis group(B group), kansui root treatment group(C group), LMWH treatment group(D group), combined treatment group(E group). The serum TNF-α,IL-6 level and the ratio of TXB2/6-keto-PGF1α in pancreatic tissue, and the histological examination were evaluated. Results ：The values ofTNF-α、IL-6 and the ratio ofTXB2/6-keto-PGF1α in C，D，E group were significantly lower than those in B group at the time point of6,12,24h. But there were no significant differences in C，D，E group at all the time points. The histological examination showed that the pancreas was normal in group A; the pathological changes were milder in C，D，E group than that in B group.Conclusions ：Combined treatment of kansui root and LMWH was effective in SAP, but there was no synergism, and also no side effects.