腹膜后纤维化的诊断与治疗进展

腹膜后纤维化是一种病因不明的胶原血管病,其特征是腹膜后慢性非特异性炎症伴纤维组织增生,包绕压迫输尿管和腹膜后腔其他脏器,继发肾盂积水,从而产生腰腹部疼痛等临床表现。影像学检查是诊断的主要手段,大体病理表现为纤维状斑块包裹腹膜后脏器。组织学早期表现为活跃的慢性炎性反应,后期可见纤维组织玻璃样变,出现纤维斑块。治疗目的为解除输尿管梗阻,保存肾功能,预防炎症进一步发展。

Progress in Diagnosis and Treatment of Retroperitoneal Fibrosis

Retroperitoneal fibrosis is a kind of collagen vascular disease with unknown etiology, charac-terized by chronic nouspecific inflammation with retroperitoneal fibrosis, wrapping oppression of ureter andretroperitoneal organs, secondary hydronephrosis, resulting in abdominal pains and other clinical manifesta-tions. Imaging examinations are major diagnostic methods, and the general pathological manifestation isfibrous plaque wrapping retroperitoneal organs. The early histological manifestations are active chronic inflam-matory reaction,later, fibrous tissue hyalinization and fibrous plaque appear. The purpose of treatment is torelieve ureteral obstruction,preserve renal functions,and prevent further development of the inflammation.