| 微小RNA-140与骨关节炎关系的研究进展 |
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| 引用本文： | 李灿锋,尤田,沈彬.微小RNA-140与骨关节炎关系的研究进展[J].中华关节外科杂志（电子版）,2020,14(1):68-72. |
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| 作者姓名： | 李灿锋 尤田 沈彬 |
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| 作者单位： | 1. 518036 深圳，北京大学深圳医院运动医学与康复医学中心；610041 成都，四川大学华西医院骨科2. 518036 深圳，北京大学深圳医院运动医学与康复医学中心3. 610041 成都，四川大学华西医院骨科 |
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| 基金项目： | 国家自然科学基金面上项目(81974347、81672219);深圳市医学三名工程项目(SZSM201612078);广东省医学科学技术研究基金项目(A2017202);广东省自然科学基金项目(2017A030310616)。 |
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| 摘 要： | 骨关节炎是一种以关节软骨退变为主的退行性疾病，但其具体发病机制目前尚不清楚。微小RNA-140(miR-140)是一种在软骨细胞中特异性高表达的microRNA，为软骨细胞调控信号网络中重要的一员，参与了软骨细胞形成、增殖、分化、衰老及凋亡的调控作用。然而，由于miR-140作用的复杂性，其参与骨关节炎(OA)软骨退变的具体分子机制目前仍不明确。本文针对miR-140在软骨形成与稳态维持、软骨退变及OA早期诊断方面的作用进行综述。
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| 关 键 词： | 微RNA 骨关节炎 软骨细胞 |
Role of microRNA-140 in pathogenesis of osteoarthritis |
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| Li Canfeng,You Tian,Shen Bin.Role of microRNA-140 in pathogenesis of osteoarthritis[J].Chinese Journal of Joint Surgery(Electronic Version),2020,14(1):68-72. |
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| Authors: | Li Canfeng You Tian Shen Bin |
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| Institution: | 1. Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen 518036, China; Department of Orthopedics, West China Hospital of Sichuan University, Chengdu 610041, China2. Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen 518036, China3. Department of Orthopedics, West China Hospital of Sichuan University, Chengdu 610041, China |
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| Abstract: | Osteoarthritis is a degenerative diseases mainly in articular cartilage,but its pathogenesis has not been elucidated yet.MicroRNA-140(miR-140)is a specific and high expression microRNA in cartilage,which plays an essential role in chondrogenesis,proliferation,mature,differentiation,aging as well as apoptosis.However,due to its complex role,the molecular mechanism of miR-140 in the pathogenesis of osteoarthritis is unclear yet.Thus,this article reviewed recent literatures in order to discuss the role of miR-140 in chondorgenesis,cartilage homeostasis and degeneration as well as early diagnosis of osteoarthritis. |
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| Keywords: | MicroRNAs Osteoarthritis Chondrocyte |
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