川芎嗪注射液治疗重症肺炎合并慢性肾功能衰竭效果

目的分析腹膜透析联合川芎嗪注射液治疗重症肺炎合并慢性肾功能衰竭(Chronic renal failure,CRF)患者的临床效果及对患者血清可溶性fms样酪氨酸激酶-1(Soluble FMS like tyrosine kinase-1,sFlt-1)、结缔组织生长因子(Connective tissue growth factor,CTGF)水平的影响。方法将2016年1月-2018年1月金华文荣医院收治的100例重症肺炎合并CRF患者随机分为研究组及对照组;对照组采用腹膜透析治疗,研究组采用腹膜透析联合川芎嗪注射液治疗;治疗结束后对患者临床疗效进行评估;在治疗前及治疗结束一周后记录患者生命体征,检测患者血气指标、肾功能指标、sFlt-1,CTGF水平。结果治疗后,研究组患者治疗总有效率为96.00%,高于对照组的82.00%(P<0.05);研究组患者心率、呼吸频率、血清肌酐(Serum creatinine,SCr)、尿素氮(Blood urea nitrogen,BUN)水平均降低(P<0.05),且研究组各指标均低于对照组(P<0.05);两组患者平均动脉压、24 h尿量、血中pH、PaO2及SaO2水平均升高(P<0.05),且研究组各指标高于对照组(P<0.05);研究组心率减慢时间、咳嗽改善时间及水肿消失时间均短于对照组(P<0.05);两组血中sFlt及CTGF水平降低(P<0.05),且研究组低于对照组(P<0.05)。结论采用腹膜透析联合川芎嗪注射液对重症肺炎合并CRF患者治疗后可有效提高临床效果,并降低患者血清sFlt-1、CTGF水平,具有较高的临床应用价值。

Effect of Ligustrazine Injection on treatment of patients with severe pneumonia complicated with chronic renal failure

OBJECTIVE To analyze the clinical effect of peritoneal dialysis combined with Ligustrazine Injection in the treatment of severe pneumonia complicated with CRF and its influence on serum sFlt-1 and CTGF levels. METHODS From Jan. 2016 to Jan. 2018, 100 patients with severe pneumonia complicated with CRF were randomly divided into the observation group and the control group. The control group was treated with peritoneal dialysis and the observation group was treated with peritoneal dialysis combined with Ligustrazine injection. After the treatment, the clinical efficacy of patients was evaluated. The vital signs of patients were recorded, and blood gas index, renal function index, sFlt-1 and CTGF were detected before and one week after the treatment.RESULTS After the treatment, the total effective rate in the observation group was 96.00%, which was significantly higher than that in the control group with 82.00%(P<0.05). The heart rate, respiratory rate, blood SCr, BUN levels in the observation group were significantly decreased after the treatment(P<0.05), and the indexes in the observation group were significantly lower than that in the control group(P<0.05). The mean arterial pressure, 24-hour urine volume, blood pH, levels of PaO2 and SaO2 in the two groups after the treatment were significantly increased(P<0.05), which were significantly higher than that in the control group(P<0.05). The heart rate slowing time, cough improving time and edema disappearing time in the observation group were significantly lower than that in the control group(P<0.05). The serum levels of sFlt and CTGF in both groups were significantly decreased after the treatment(P<0.05), and the indexes in the observation group was significantly lower than that in the control group(P<0.05). CONCLUSION Peritoneal dialysis combined with tetramethylpyrazine injection can improve the clinical efficiency in the treatment of severe pneumonia complicated with CRF and decrease the serum levels of sFlt-1、CTGF, which may offer the clinical valuease the serum levels of sFlt-1、CTGF, which may offer the clinical value.