解脲支原体与女性膀胱黏膜白斑发病机制的关联性研究

目的探讨解脲支原体（UU）感染与女性膀胱黏膜白班病变的关联性。 方法对具有下尿路症状的女性入组患者(排除神经源性膀胱、下尿路细菌感染、膀胱及尿道结石、膀胱过度活动症、泌尿系结核及膀胱肿瘤等)进行尿道分泌物PCR-DNA检测解脲支原体及沙眼衣原体（CT），及膀胱镜下对膀胱黏膜病变组织与病变旁3～5 cm的膀胱黏膜组织活检，并行病理诊断是否有白斑病变。同时对活检组织进行免疫组化检测UU抗原及CT抗原，通过对比检测结果来阐明UU与CT感染与膀胱黏膜白斑病变的关联性。 结果UU抗原在膀胱黏膜白斑组织表达水平高于白斑旁黏膜组织中的表达，而CT抗原的表达率差异无统计学意义。 结论UU感染与膀胱黏膜白斑病变具有关联性。

Association study of the pathogenesis between ureaplasma urealyticum and female vesical mucosa leukoplakia

ObjectiveTo investigate the association of the pathogenesis between ureaplasma urealyticum and female vesical mucosa leukoplakia. MethodsFemale patients with lower urinary tract symptoms (excluding neurogenic bladder, lower urinary tract bacterial infection, bladder and urethral calculi, overactive bladder, urinary system tuberculosis and bladder tumor, etc.) were enrolled into the study, and urethral secretion of ureaplasma urealyticum (UU) and chlamydia trachomatis (CT) were detected by PCR-DNA. Cystoscope biopsy was performed on the central tissue of the bladder mucosa and tissue 3-5 cm beside it. Pathologic examination was conducted to determine whether leukoplakia was present. Immunohistochemical detection for the biopsy tissue of UU and CT antigen were performed, to comparing the test results to illustrate the correlation of UU infection and bladder mucosa white spot lesions. ResultsThe expression level of UU antigen in the leukoplakia of the bladder mucosa was higher than that in the tissue beside the leukoplakia, while the expression rate of CT antigen was not different. ConclusionUU infection is associated with leukoplakia of bladder mucosa.